Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes. - Archive ouverte HAL Access content directly
Journal Articles Nano Letters Year : 2017

Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.

Abstract

We atomistically compute the change in free energy upon binding of the globular domain of the complement protein C1q to carbon nanotubes (CNTs) and graphene in solution. Our modeling results imply that C1q is able to disaggregate and disperse bundles of large diameter multiwalled CNTs but not those of thin single-walled CNTs, and we validate this prediction with experimental observations. The results support the view of a strong binding with potential implications for the understanding of the immune response and biomedical applications of graphitic nanomaterials.
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Dates and versions

hal-01538740 , version 1 (14-06-2017)

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M. Saint-Cricq, J. Carrete, Christine Gaboriaud, E Gravel, E Doris, et al.. Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.. Nano Letters, 2017, 17 (6), pp.3409 - 3415. ⟨10.1021/acs.nanolett.7b00189⟩. ⟨hal-01538740⟩
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