Effets à long terme des modifications de la composition du lait induites par une alimentation obésogène chez la lapine - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2016

Effets à long terme des modifications de la composition du lait induites par une alimentation obésogène chez la lapine

Résumé

It has been clearly demonstrated that the maternal nutritional status during pregnancy and lactation has long-term effects on offspring health. In mammals, milk represents the first maternal support provided to the newborns so that its composition may play a major role in long-term programming. We therefore assessed the effects of maternal high-fat/high-sugar obesogenic (OD) or control (CD) diets on offspring growth and adiposity in the rabbit. Between 7 and 20 weeks of age, the body weight gain of OD milk fed rabbits was higher than that of CD milk fed rabbits (P <0.05). Body fat mass measurements at 21 weeks of age revealed a significant increase in body adiposity as a function of milk ingested during the neonatal period, in both female and male offspring (P <0.05). A marked weight gain difference was observed according to the milk in both female and male offspring. Moreover we investigated the composition in major proteins and leptin levels in milk from OD or CD fed dams. LC-MS analysis of individual control skimmed milk samples enabled identification and quantification of the rabbit main milk proteins and of their main phosphorylated isoforms at two different stages of lactation (3 and 10 days). Here we show that the OD diet induced a reduction in the whey acidic protein (WAP) content concomitantly with both an increase in serum albumin and lactoferrin contents and in the phosphorylated isoforms of the main milk proteins. Furthermore, a sharp rise in leptin levels was observed in the milk of OD fed dams on day 10 of lactation when compared to CD animals (P <0.05). Taken together these findings provide evidence that lactation is a critical window of development during which exposure to a deleterious diet is highly detrimental to long-term outcomes. Moreover, these insights suggest that it may be possible to prevent at least some of the adverse effects of inadequate maternal nutrition on the long-term metabolic outcomes of the offspring nutritional through nutritional interventions applied during the lactation period.
Fichier non déposé

Dates et versions

hal-01533919 , version 1 (06-06-2017)

Identifiants

  • HAL Id : hal-01533919 , version 1
  • PRODINRA : 382066

Citer

Catherine Hue-Beauvais, Madia Charlier. Effets à long terme des modifications de la composition du lait induites par une alimentation obésogène chez la lapine. 3. congrès de la Société francophone pour la recherche et l'éducation sur les Origines Développementales Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD), Dec 2016, Paris, France. ⟨hal-01533919⟩
58 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More