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Journal Articles Nature Communications Year : 2017

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

C. Adema (1) , L. Hillier (2) , C. Jones (3) , E.S. Loker (1) , M. Knight (4, 5) , P. Minx (2) , G. Oliveira (6) , N. Raghavan (7) , A. Shedlock (8) , L. Amaral (9) , H. Arican-Goktas (10) , J. Assis (6) , E. Baba (6) , O. Baron (11) , C. Bayne (12) , Utibe P Bickham-Wright (13) , Kyle K. Biggar (14) , M.S. Blouin (12) , B. Bonning (15) , Chris Botka (16) , J. Bridger (10) , K. Buckley (17) , S. Buddenborg (1) , R. Caldeira (6) , J. Carleton (18) , O. Carvalho (6) , M. Castillo (19) , I. Chalmers (20) , M. Christensens (21) , S. Clifton (2) , Christine Coustau (11) , R. Cripps (19) , Y. Cuesta-Astroz (6) , S. Cummins (22) , L. Di Stefano (23) , N. Dinguirard (13) , David Duval (24) , S. Emrich (25) , Cédric Feschotte (18) , René Feyereisen (11, 26) , P. Fitzgerald (27) , Catrina Fronick (2) , L. Fulton (2) , Richard Galinier (24) , Sandra G. Gava (6) , M. Geusz (28) , Kathrin K. Geyer (20) , G.I. Giraldo-Calderón (25) , Matheus de Souza Gomes (9) , M. Gordy (28) , Benjamin Gourbal (24) , Christoph Grunau (24) , P. Hanington (29) , K.F. Hoffmann (20) , D. Hughes (21) , J. Humphries (30) , Daniel J. Jackson (31) , Liana K. Jannotti-Passos (6) , Wander de Jesus Jeremias (6) , Susan Jobling (32) , Bishoy Kamel (33) , Aurélie Kapusta (18) , Satwant Kaur (32) , Joris M Koene (34) , Andrea B. Kohn (35) , Dan Lawson (21) , Scott P. Lawton (36) , Di Liang (37) , Yanin Limpanont (22) , Sijun Liu (15) , Anne E. Lockyer (32) , Tyanna L. Lovato (19) , Fernanda Ludolf (6) , Vince Magrini (2) , Donald P Mcmanus (38) , Mónica Medina (39) , Milind Misra (1) , Guillaume Mitta (24) , Gerald M. Mkoji (40) , Michael J. Montague (41) , Cesar Montelongo (19) , Leonid L. Moroz (35) , Monica Muñoz-Torres (42) , Umar P Niazi (20) , Leslie Noble (3) , Francislon S. Oliveira (6) , Fabiano S. Pais (6) , Anthony T. Papenfuss (23, 43) , Rob Peace (44) , Janeth J. Pena (1) , Emmanuel A. Pila (29) , Titouan Quelais (24) , Brian J B. J. Raney (45) , Jonathan P Rast (17) , David Rollinson (46) , Izinara C. Rosse (6) , Bronwyn Rotgans (1) , Edwin J. Routledge (10) , Kathryn M. Ryan (1) , Larissa L.S. Scholte, (6) , K. Storey (14) , Martin Swain (20) , J.A. Tennessen (12) , C. Tomlinson (2) , David Trujillo (1) , E. Volpi (47) , A.J. Walker (48) , T. Wang (37) , I. Wannaporn (1) , W. Warren (1) , X.J. Wu (1) , T.P. Yoshino (1) , M. Yusuf (1) , S.M. Zhang (1) , M. Zhao (1) , R. Wilson (1) , Celine Cosseau (24)
1 CETI - Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico]
2 MGI - The McDonnell Genome Institute
3 INSTITUTE OF BIOLOGICAL AND ENVIRONMENTAL SCIENCES
4 Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty
5 Division of Science & Mathematics
6 Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil]
7 Sans affiliation
8 Biology Department
9 Laboratory of Bioinformatics and Molecular Analysis
10 Department of Life Sciences, College of Health and Life Sciences
11 ISA - Institut Sophia Agrobiotech
12 Department of Integrative Biology
13 Department of Pathobiological Sciences
14 Institute of Biochemisty and Department of Biology
15 ISU - Iowa State University
16 Department of Information Technology, Harvard Medical School
17 Sunnybrook Health Sciences Centre, Department of Immunology
18 Department of Human Genetics [Salt Lake City]
19 Biology, New Mexico State University
20 IBERS - Institute of Biological, Environmental and Rural Sciences
21 EMBL-EBI - European Bioinformatics Institute [Hinxton]
22 Faculty of Science, Health and Education
23 WEHI - The Walter and Eliza Hall Institute of Medical Research
24 IHPE - Interactions Hôtes-Pathogènes-Environnements
25 Genomics and Bioinformatics Core Facility
26 Department of Plant and Environmental Sciences [Copenhagen]
27 Genome Analysis Unit, National Cancer Institute
28 Biological Sciences, Bowling Green State University
29 University of Alberta
30 Department of Biology, Lawrence University
31 Georg-August-University = Georg-August-Universität Göttingen
32 Institute of Environment, Health & Societies, Environment and Health Theme, Brunel University London
33 Department of Biology
34 Faculteit der Aard- en Levenswetenschappen, Vrije Universiteit
35 The Whitney Laboratory for Marine Bioscience, University of Florida
36 Molecular Parasitology Laboratory, Kingston University
37 USC - Faculty of Science, Health, Education and Engineering
38 Molecular Parasitology Unit
39 Penn State - Pennsylvania State University
40 KEMRI - Kenya Medical Research Institute
41 DEPARTMENT OF NEUROSCIENCE - Department of Neuroscience
42 LBNL - Lawrence Berkeley National Laboratory [Berkeley]
43 Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli
44 Carleton University
45 Institute for Genomics and Bioinformatics [Irvine]
46 Parasites and Vectors Division, London Centre for Neglected Tropical Disease Research
47 Department of Biomedical Sciences, Faculty of Science and Technology
48 Molecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry
N. Raghavan
  • Function : Author
A. Shedlock
  • Function : Author
B. Bonning
  • Function : Author
David Duval
Sijun Liu
  • Function : Author
Rob Peace
  • Function : Author

Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis
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hal-01523953 , version 1 (17-05-2017)

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C. Adema, L. Hillier, C. Jones, E.S. Loker, M. Knight, et al.. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 2017, 8, pp.15451. ⟨10.1038/ncomms15451⟩. ⟨hal-01523953⟩
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