Translation of rod-like template sequences into homochiral assemblies of stacked helical oligomers
Résumé
Translating a molecular sequence into a chemically different sequence has been powerfully exploited by nature, for example to produce proteins from mRNA templates. Yet, artificial systems inspired from this process are rare and far from optimized. Here we show that rod-like oligocarbamates may template the formation of well-defined sequences of stacked aromatic amide helices wound around them. Features of the rods, including the number and distance between carbamate functions and the presence of stereogenic centres, template the high fidelity formation of complementary stacks of helices each having a defined handedness, length and single or double helicity, through a self-assembly process allowing error correction. The outcome is unprecedentedly large abiotic folded architectures that may serve as scaffolds to organize appended functional features at positions in space defined with atomic precision across nanometric distances.
Domaines
Chimie organique
Origine : Fichiers produits par l'(les) auteur(s)
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