Early multisensory perceptual experiences shape the abilities of infants to perform socially-relevant visual categorization, such as the extraction of gender, age, and emotion from faces. Here, we investigated whether multisensory perception of gender is influenced by infant-directed (IDS) or adult-directed (ADS) speech. Six-, 9-, and 12-month-old infants saw side-by-side silent video-clips of talking faces (a male and a female) and heard either a soundtrack of a female or a male voice telling a story in IDS or ADS. Infants participated in only one condition, either IDS or ADS. Consistent with earlier work, infants displayed advantages in matching female relative to male faces and voices. Moreover, the new finding that emerged in the current study was that extraction of gender from face and voice was stronger at 6 months with ADS than with IDS, whereas at 9 and 12 months, matching did not differ for IDS versus ADS. The results indicate that the ability to perceive gender in audiovisual speech is influenced by speech manner. Our data suggest that infants may extract multisen-sory gender information developmentally earlier when looking at adults engaged in conversation with other adults (i.e., ADS) than when adults are directly talking to them (i.e., IDS). Overall, our findings imply that the circumstances of social interaction may shape early mul-tisensory abilities to perceive gender.