Pentacyclic triterpenes from Manilkara bidentata resin. Isolation, identification and biological properties - Archive ouverte HAL
Article Dans Une Revue Fitoterapia Année : 2013

Pentacyclic triterpenes from Manilkara bidentata resin. Isolation, identification and biological properties

Résumé

Three pentacyclic triterpenes were isolated for the first time from resinous plant Manilkara bidentata. Ultrasound-assisted extraction with ethanol was chosen after a comparison of various extraction methods. Analysis of the extract was performed by HPLC with evaporative light scattering detection and semi-preparative HPLC has enabled us to isolate two urs-12-enes (3 beta-O-acetyl-alpha-amyrin and 3 beta-O-trans cinnamyl-alpha-amyrin) and a lupane-type derivative (3 beta-O-trans cinnamyl lupeol). Structures were elucidated on the basis of HRESIMS, atmospheric pressure photoionization MS, and homo- and heteronuclear correlation NMR experiments. Antioxidant and anti-inflammatory activities were determined on Manilkara extract and isolated fractions. We have also investigated their action on collagen and fibronectin synthesis, two very important proteins of the extracellular matrix. Thus, Manilkara extract was able to decrease IL-1 beta and IL-8 pro-inflammatory cytokines. These activities exhibit the potential use of Manilkara extract as an anti-inflammatory and anti-aging ingredient for pharmaceutical and cosmetic industries.

Dates et versions

hal-01518901 , version 1 (05-05-2017)

Identifiants

Citer

Boutayna Rhourri-Frih, Isabelle Renimel, Patrick Chaimbault, Patrice André, Gaëtan Herbette, et al.. Pentacyclic triterpenes from Manilkara bidentata resin. Isolation, identification and biological properties. Fitoterapia, 2013, 88, pp.101-108. ⟨10.1016/j.fitote.2013.05.001⟩. ⟨hal-01518901⟩
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