In France, Hospital-at-Home Services (HHS) providers that employ their caregivers have to define the assignment of patients to caregivers and the planning of the caregivers’ routes. In the literature, different approaches are proposed to deal with both these problems. Our aim in this paper is to present a literature review of such researches. The target is to show how operational research approaches and Multi-agent based methods can be combined and generate a “win-win” relationship between both approaches to solve HHS resources management in operational level.