<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01515296</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T00:49:07+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer's Disease</title>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Sébastien</forename>
                <surname>Vidal</surname>
              </persName>
              <idno type="halauthorid">232757-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Hanon</surname>
              </persName>
              <email type="md5">384fd5e7ca860672fe35eeae56f60d4c</email>
              <email type="domain">brc.ap-hop-paris.fr</email>
              <idno type="idhal" notation="numeric">1340950</idno>
              <idno type="halauthorid" notation="string">234929-1340950</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4697-122X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoît</forename>
                <surname>Funalot</surname>
              </persName>
              <idno type="halauthorid">587738-0</idno>
              <affiliation ref="#struct-122857"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadege</forename>
                <surname>Brunel</surname>
              </persName>
              <email type="md5">33718228edc6acb4c4257daa67dc92a6</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">nadege-brunel</idno>
              <idno type="idhal" notation="numeric">182320</idno>
              <idno type="halauthorid" notation="string">1164584-182320</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cécile</forename>
                <surname>Viollet</surname>
              </persName>
              <email type="md5">bd97567fa0c168095052ee6b0f369285</email>
              <email type="domain">espci.fr</email>
              <idno type="idhal" notation="string">cecile-viollet</idno>
              <idno type="idhal" notation="numeric">178182</idno>
              <idno type="halauthorid" notation="string">4749-178182</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5171-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1302-2404</idno>
              <idno type="IDREF">https://www.idref.fr/142830852</idno>
              <affiliation ref="#struct-122857"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Sophie</forename>
                <surname>Rigaud</surname>
              </persName>
              <email type="md5">a822254c3c4d73857dc31e6a8b798180</email>
              <email type="domain">aphp.fr</email>
              <idno type="idhal" notation="numeric">1013048</idno>
              <idno type="halauthorid" notation="string">234933-1013048</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6827-4417</idno>
              <idno type="IDREF">https://www.idref.fr/070436908</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Laure</forename>
                <surname>Seux</surname>
              </persName>
              <idno type="halauthorid">1165110-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Le-Bouce</surname>
              </persName>
              <idno type="halauthorid">1165111-0</idno>
              <affiliation ref="#struct-103080"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacques</forename>
                <surname>Epelbaum</surname>
              </persName>
              <email type="md5">b91b4961b9698cd1f527ccd2c06a1a04</email>
              <email type="domain">broca.inserm.fr</email>
              <idno type="idhal" notation="numeric">836901</idno>
              <idno type="halauthorid" notation="string">170860-836901</idno>
              <affiliation ref="#struct-122857"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuelle</forename>
                <surname>Duron</surname>
              </persName>
              <idno type="halauthorid">694593-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Gestionnaire</forename>
                <surname>HAL-UPMC</surname>
              </persName>
              <email type="md5">5e5f92b30d5a5dc773d73b514d0dc0a4</email>
              <email type="domain">upmc.fr</email>
            </editor>
            <funder>French Ministry of Health (PHRCN) SIGAL (Study of IGF system on ALzheimer's disease)</funder>
            <funder> Inserm</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-04-27 11:57:42</date>
              <date type="whenModified">2025-09-22 17:56:05</date>
              <date type="whenReleased">2017-04-27 11:57:42</date>
              <date type="whenProduced">2016</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="320703">
                <persName>
                  <forename>Gestionnaire</forename>
                  <surname>HAL-UPMC</surname>
                </persName>
                <email type="md5">5e5f92b30d5a5dc773d73b514d0dc0a4</email>
                <email type="domain">upmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01515296</idno>
            <idno type="halUri">https://hal.science/hal-01515296</idno>
            <idno type="halBibtex">vidal:hal-01515296</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Alzheimer's Disease&lt;/i&gt;, 2016, 52 (2), pp.641-649. &lt;a target="_blank" href="https://dx.doi.org/10.3233/JAD-151162"&gt;&amp;#x27E8;10.3233/JAD-151162&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Alzheimer's Disease, 2016, 52 (2), pp.641-649. &amp;#x27E8;10.3233/JAD-151162&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="U938" corresp="SORBONNE-UNIVERSITE">Centre de recherche Saint-Antoine - UMR S938</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="OMIQUE" corresp="SORBONNE-UNIVERSITE">Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé - UMS 37 PASS</idno>
            <idno type="stamp" n="OMIQUE-FLUEXGEN" corresp="OMIQUE">Plateforme FluExGen</idno>
            <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer's Disease</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Sébastien</forename>
                    <surname>Vidal</surname>
                  </persName>
                  <idno type="halauthorid">232757-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Hanon</surname>
                  </persName>
                  <email type="md5">384fd5e7ca860672fe35eeae56f60d4c</email>
                  <email type="domain">brc.ap-hop-paris.fr</email>
                  <idno type="idhal" notation="numeric">1340950</idno>
                  <idno type="halauthorid" notation="string">234929-1340950</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4697-122X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoît</forename>
                    <surname>Funalot</surname>
                  </persName>
                  <idno type="halauthorid">587738-0</idno>
                  <affiliation ref="#struct-122857"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadege</forename>
                    <surname>Brunel</surname>
                  </persName>
                  <email type="md5">33718228edc6acb4c4257daa67dc92a6</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">nadege-brunel</idno>
                  <idno type="idhal" notation="numeric">182320</idno>
                  <idno type="halauthorid" notation="string">1164584-182320</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cécile</forename>
                    <surname>Viollet</surname>
                  </persName>
                  <email type="md5">bd97567fa0c168095052ee6b0f369285</email>
                  <email type="domain">espci.fr</email>
                  <idno type="idhal" notation="string">cecile-viollet</idno>
                  <idno type="idhal" notation="numeric">178182</idno>
                  <idno type="halauthorid" notation="string">4749-178182</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5171-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1302-2404</idno>
                  <idno type="IDREF">https://www.idref.fr/142830852</idno>
                  <affiliation ref="#struct-122857"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Sophie</forename>
                    <surname>Rigaud</surname>
                  </persName>
                  <email type="md5">a822254c3c4d73857dc31e6a8b798180</email>
                  <email type="domain">aphp.fr</email>
                  <idno type="idhal" notation="numeric">1013048</idno>
                  <idno type="halauthorid" notation="string">234933-1013048</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6827-4417</idno>
                  <idno type="IDREF">https://www.idref.fr/070436908</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Laure</forename>
                    <surname>Seux</surname>
                  </persName>
                  <idno type="halauthorid">1165110-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Le-Bouce</surname>
                  </persName>
                  <idno type="halauthorid">1165111-0</idno>
                  <affiliation ref="#struct-103080"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacques</forename>
                    <surname>Epelbaum</surname>
                  </persName>
                  <email type="md5">b91b4961b9698cd1f527ccd2c06a1a04</email>
                  <email type="domain">broca.inserm.fr</email>
                  <idno type="idhal" notation="numeric">836901</idno>
                  <idno type="halauthorid" notation="string">170860-836901</idno>
                  <affiliation ref="#struct-122857"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuelle</forename>
                    <surname>Duron</surname>
                  </persName>
                  <idno type="halauthorid">694593-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22009</idno>
                <idno type="issn">1387-2877</idno>
                <idno type="eissn">1875-8908</idno>
                <title level="j">Journal of Alzheimer's Disease</title>
                <imprint>
                  <publisher>IOS Press</publisher>
                  <biblScope unit="volume">52</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">641-649</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3233/JAD-151162</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en"> insulin-like growth factor-I</term>
                <term xml:lang="en"> cognitive decline</term>
                <term xml:lang="en">Alzheimer's disease</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: The relationship between the insulin-like growth factor-I (IGF-I) system and Alzheimer's disease (AD) is mostly based on transversal studies. It remains, however, to demonstrate whether IGF-I is associated with cognitive decline over time in AD. Objective: The objective of the study was to analyze the course of cognitive decline of AD subjects over a 24-month period in relation to serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) measured at baseline. Methods: Data are from the SIGAL follow-up study. IGF-I and IGFBP-3 were measured in AD subjects who performed a Mini-Mental State Examination (MMSE) every 6 months for 2 years. MMSE course was analyzed using a mixed model with random intercept and slope function. Results: Among the 200 AD participants, 146 (mean age = 81.1 (standard deviation (SD) = 5.9) years, 62.6% of women) had at least one follow-up visit. Mean IGF-I at baseline was 147.8 (74.2) ng/mL. Hundred forty-six participants (62.6%) had at least one follow-up visit. Mean MMSE was 21.7 (4.7)/30 and dropped on average by 2.28 points per year. MMSE decline was steeper among participants with lower IGF-I. For each decrease of 1 SD of IGF-I, subjects lost an additional 0.63 points per year in MMSE, e.g., participants with IGF-I level of 74 ng/mL lost 2.91 MMSE points per year whereas participants with IGF-I of 222 ng/mL lost 1.65 MMSE points per year. There was no association between IGFBP-3 and cognitive decline. Conclusion: Lower baseline serum IGF-I was associated with faster cognitive decline in AD over a 2-year period.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-122857" status="OLD">
          <idno type="RNSR">200816530M</idno>
          <orgName>Centre de Psychiatrie et Neurosciences</orgName>
          <orgName type="acronym">U894</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2018-12-31</date>
          <desc>
            <address>
              <addrLine>Centre de Psychiatrie et Neurosciences 102-108 Rue de la Santé75014 PARIS</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR_S 894" active="#struct-301664" type="direct"/>
            <relation name="UMR_S 894" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-103080" status="OLD">
          <orgName>Centre de Recherche Saint-Antoine</orgName>
          <orgName type="acronym">UMRS893</orgName>
          <desc>
            <address>
              <addrLine>75012 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-93591" type="direct"/>
            <relation name="U893" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-93591" status="OLD">
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>