Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State
Résumé
Quinoline-based oligoamide foldamers have been identified as a potent class of G-quadruplex DNA ligands. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report the cocrystal structure of anti-parallel hairpin dimeric DNA G-quadruplex (G4T4G4)2 with a helically folded tetra-quinolinecarboxamide bearing cationic side chain consistent with this hypothesis. Multivalent foldamer-DNA interactions are observed that modify the packing of (G4T4G4)2 in the solid state.
Domaines
Chimie
Origine : Fichiers produits par l'(les) auteur(s)
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