Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemBioChem Année : 2016

Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State

Résumé

Quinoline-based oligoamide foldamers have been identified as a potent class of G-quadruplex DNA ligands. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report the cocrystal structure of anti-parallel hairpin dimeric DNA G-quadruplex (G4T4G4)2 with a helically folded tetra-quinolinecarboxamide bearing cationic side chain consistent with this hypothesis. Multivalent foldamer-DNA interactions are observed that modify the packing of (G4T4G4)2 in the solid state.

Domaines

Chimie
Fichier principal
Vignette du fichier
ChemBioChem_v4.pdf (375.5 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01509479 , version 1 (18-04-2017)

Identifiants

Citer

Pradeep K. Mandal, Benoît Baptiste, Béatrice Langlois d'Estaintot, Brice Kauffmann, Ivan Huc. Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State. ChemBioChem, 2016, 17 (20), pp.1911-1914. ⟨10.1002/cbic.201600281⟩. ⟨hal-01509479⟩

Collections

CNRS INC-CNRS
36 Consultations
194 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More