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Article Dans Une Revue Applied Physics Letters Année : 2012

Atmospheric-pressure guided streamers for liposomal membrane disruption

P. Svarnas
  • Fonction : Auteur
S. H. Matrali
  • Fonction : Auteur
K. Gazeli
  • Fonction : Auteur
Sp. Aleiferis
  • Fonction : Auteur
S. G. Antimisiaris
  • Fonction : Auteur

Résumé

The potential to use liposomes (LIPs) as a cellular model in order to study interactions of cold atmospheric-pressure plasma with cells is herein investigated. Cold atmospheric-pressure plasma is formed by a dielectric-barrier discharge reactor. Large multilamellar vesicle liposomes, consisted of phosphatidylcholine and cholesterol, are prepared by the thin film hydration technique, to encapsulate a small hydrophilic dye, i.e., calcein. The plasma-induced release of calcein from liposomes is then used as a measure of liposome membrane integrity and, consequently, interaction between the cold atmospheric plasma and lipid bilayers. Physical mechanisms leading to membrane disruption are suggested, based on the plasma characterization including gas temperature calculation.

Domaines

Plasmas
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Dates et versions

hal-01503055 , version 1 (06-04-2017)

Identifiants

Citer

P. Svarnas, S. H. Matrali, K. Gazeli, Sp. Aleiferis, Franck Clement, et al.. Atmospheric-pressure guided streamers for liposomal membrane disruption. Applied Physics Letters, 2012, 101 (264103), pp.1-5. ⟨10.1063/1.4773201⟩. ⟨hal-01503055⟩
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