This paper presents a review of time-series analysis of road safety trends, aggregated at a national level, which has been performed in the period 2000-2012 and applied to European national data sets covering long time periods. It provides a guideline and set of best practices in the area of time-series modelling and identifies the latest methods and applications of national road safety trend analysis in Europe. The paper begins with the methodological framework adopted for aggregate time-series modelling that will be considered, and then discusses a number of relevant applications to long-period data aggregated at the national level, whether for countries alone, or for groups of countries. Some analyses, which were performed at the disaggregated level, are also provided, as they are being used more and more. Finally, the paper summarizes and discusses the significant changes in aggregate road safety trend analysis which occurred during the period and provides recommendations for continuing these research efforts.