Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Soft Matter Année : 2016

Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances

L. Zerkoune
  • Fonction : Auteur
S. Lesieur
L. Choisnard
  • Fonction : Auteur
A. Geze
  • Fonction : Auteur
D. Wouessidjewe
  • Fonction : Auteur
B. Angelov
  • Fonction : Auteur
J. Doutch
  • Fonction : Auteur
A. Angelova
  • Fonction : Auteur

Résumé

Soft mesoporous hierarchically structured particles were created by the self-assembly of an amphiphilic deep cavitand cyclodextrin βCD-nC10 (degree of substitution n = 7.3), with a nanocavity grafted by multiple alkyl (C10) chains on the secondary face of the βCD macrocycle through enzymatic biotransesterification, and the nonlamellar lipid monoolein (MO). The effect of the non-ionic dispersing agent polysorbate 80 (P80) on the liquid crystalline organization of the nanocarriers and their stability was studied in the context of vesicle-to-cubosome transition. The coexistence of small vesicular and nanosponge membrane objects with bigger nanoparticles with inner multicompartment cubic lattice structures was established as a typical feature of the employed dispersion process. The cryogenic transmission electron microscopy (cryo-TEM) images and small-angle X-ray scattering (SAXS) structural analyses revealed the dependence of the internal organization of the self-assembled nanoparticles on the presence of embedded βCD-nC10 deep cavitands in the lipid bilayers. The obtained results indicated that the incorporated amphiphilic βCD-nC10 building blocks stabilize the cubic lattice packing in the lipid membrane particles, which displayed structural features beyond the traditional CD nanosponges. UV-Vis spectroscopy was employed to characterize the nanoencapsulation of a model hydrophobic dimethylphenylazo-naphthol guest compound (Oil red) in the created nanocarriers. In perspective, these dual porosity carriers should be suitable for co-encapsulation and sustained delivery of peptide, protein or siRNA biopharmaceuticals together with small molecular weight drug compounds or imaging agents. © 2016 The Royal Society of Chemistry.
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Dates et versions

hal-01495811 , version 1 (15-12-2023)

Identifiants

Citer

L. Zerkoune, S. Lesieur, J.-L. Putaux, L. Choisnard, A. Geze, et al.. Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances. Soft Matter, 2016, 12 (36), pp.7539--7550. ⟨10.1039/c6sm00661b⟩. ⟨hal-01495811⟩
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