<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01492673</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-09T01:52:32+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term</title>
            <author role="aut">
              <persName>
                <forename type="first">Meriam</forename>
                <surname>Koob</surname>
              </persName>
              <email type="md5">e3c4bda4107909a427579bbace16107a</email>
              <email type="domain">chru-strasbourg.fr</email>
              <idno type="idhal" notation="numeric">938000</idno>
              <idno type="halauthorid" notation="string">1066499-938000</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3594-6272</idno>
              <idno type="IDREF">https://www.idref.fr/069014620</idno>
              <affiliation ref="#struct-300093"/>
              <affiliation ref="#struct-217648"/>
              <affiliation ref="#struct-186337"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Angèle</forename>
                <surname>Viola</surname>
              </persName>
              <email type="md5">aab1b6edf48eae4309053babd14b6373</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">angele-viola</idno>
              <idno type="idhal" notation="numeric">750541</idno>
              <idno type="halauthorid" notation="string">27949-750541</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yann</forename>
                <surname>Le Fur</surname>
              </persName>
              <idno type="idhal" notation="numeric">756936</idno>
              <idno type="halauthorid" notation="string">161694-756936</idno>
              <idno type="IDREF">https://www.idref.fr/16766350X</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Viout</surname>
              </persName>
              <idno type="halauthorid">161682-0</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Ratiney</surname>
              </persName>
              <email type="md5">ccb8f9ed6d1e7e875743956cdc7e3a1a</email>
              <email type="domain">creatis.insa-lyon.fr</email>
              <idno type="idhal" notation="string">helene-ratiney</idno>
              <idno type="idhal" notation="numeric">19210</idno>
              <idno type="halauthorid" notation="string">895861-19210</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-4186-2014</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0662-2172</idno>
              <idno type="IDREF">https://www.idref.fr/084342625</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-4186-2014</idno>
              <affiliation ref="#struct-530749"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylviane</forename>
                <surname>Confort-Gouny</surname>
              </persName>
              <email type="md5">209604919778fd4205fe4501e8c0c9a4</email>
              <email type="domain">univmed.fr</email>
              <idno type="idhal" notation="string">sylviane-confort-gouny</idno>
              <idno type="idhal" notation="numeric">11157</idno>
              <idno type="halauthorid" notation="string">15601-11157</idno>
              <idno type="IDREF">https://www.idref.fr/161489079</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8234-7467</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <forename type="middle">J</forename>
                <surname>Cozzone</surname>
              </persName>
              <idno type="halauthorid">1138860-0</idno>
              <affiliation ref="#struct-480402"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadine</forename>
                <surname>Girard</surname>
              </persName>
              <idno type="halauthorid">707068-0</idno>
              <affiliation ref="#struct-480402"/>
              <affiliation ref="#struct-300093"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Béatrice</forename>
                <surname>Rayet</surname>
              </persName>
              <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
              <email type="domain">creatis.insa-lyon.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-03-20 14:03:31</date>
              <date type="whenModified">2026-04-23 14:50:05</date>
              <date type="whenReleased">2017-03-20 14:07:37</date>
              <date type="whenProduced">2016</date>
              <date type="whenEndEmbargoed">2017-03-20</date>
              <ref type="file" target="https://hal.science/hal-01492673v1/document">
                <date notBefore="2017-03-20"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-01492673v1/file/journal.pone.0160990.pdf" id="file-1492673-1556518">
                <date notBefore="2017-03-20"/>
              </ref>
              <ref type="externalLink" target="https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0160990&amp;type=printable"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="180336">
                <persName>
                  <forename>Béatrice</forename>
                  <surname>Rayet</surname>
                </persName>
                <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
                <email type="domain">creatis.insa-lyon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01492673</idno>
            <idno type="halUri">https://hal.science/hal-01492673</idno>
            <idno type="halBibtex">koob:hal-01492673</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS ONE&lt;/i&gt;, 2016, 11 (8), pp.0160990. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0160990"&gt;&amp;#x27E8;10.1371/journal.pone.0160990&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS ONE, 2016, 11 (8), pp.0160990. &amp;#x27E8;10.1371/journal.pone.0160990&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1492673-1556518"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="ENGEES">Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg</idno>
            <idno type="stamp" n="CRMBM">Centre de Résonance Magnétique Biologique et Médicale</idno>
            <idno type="stamp" n="CREATIS" corresp="UNIV-LYON1">Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="INSA-STRASBOURG">Institut National des Sciences Appliquées de Strasbourg</idno>
            <idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno>
            <idno type="stamp" n="PRIMES_WP2" corresp="PRIMES">WP2: Techniques innovantes d'imagerie</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="UMR7357">Laboratoire des sciences de l’ingénieur, de l’informatique et de l’imagerie</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Meriam</forename>
                    <surname>Koob</surname>
                  </persName>
                  <email type="md5">e3c4bda4107909a427579bbace16107a</email>
                  <email type="domain">chru-strasbourg.fr</email>
                  <idno type="idhal" notation="numeric">938000</idno>
                  <idno type="halauthorid" notation="string">1066499-938000</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3594-6272</idno>
                  <idno type="IDREF">https://www.idref.fr/069014620</idno>
                  <affiliation ref="#struct-300093"/>
                  <affiliation ref="#struct-217648"/>
                  <affiliation ref="#struct-186337"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angèle</forename>
                    <surname>Viola</surname>
                  </persName>
                  <email type="md5">aab1b6edf48eae4309053babd14b6373</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">angele-viola</idno>
                  <idno type="idhal" notation="numeric">750541</idno>
                  <idno type="halauthorid" notation="string">27949-750541</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yann</forename>
                    <surname>Le Fur</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">756936</idno>
                  <idno type="halauthorid" notation="string">161694-756936</idno>
                  <idno type="IDREF">https://www.idref.fr/16766350X</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Viout</surname>
                  </persName>
                  <idno type="halauthorid">161682-0</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Ratiney</surname>
                  </persName>
                  <email type="md5">ccb8f9ed6d1e7e875743956cdc7e3a1a</email>
                  <email type="domain">creatis.insa-lyon.fr</email>
                  <idno type="idhal" notation="string">helene-ratiney</idno>
                  <idno type="idhal" notation="numeric">19210</idno>
                  <idno type="halauthorid" notation="string">895861-19210</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-4186-2014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0662-2172</idno>
                  <idno type="IDREF">https://www.idref.fr/084342625</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-4186-2014</idno>
                  <affiliation ref="#struct-530749"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylviane</forename>
                    <surname>Confort-Gouny</surname>
                  </persName>
                  <email type="md5">209604919778fd4205fe4501e8c0c9a4</email>
                  <email type="domain">univmed.fr</email>
                  <idno type="idhal" notation="string">sylviane-confort-gouny</idno>
                  <idno type="idhal" notation="numeric">11157</idno>
                  <idno type="halauthorid" notation="string">15601-11157</idno>
                  <idno type="IDREF">https://www.idref.fr/161489079</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8234-7467</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <forename type="middle">J</forename>
                    <surname>Cozzone</surname>
                  </persName>
                  <idno type="halauthorid">1138860-0</idno>
                  <affiliation ref="#struct-480402"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadine</forename>
                    <surname>Girard</surname>
                  </persName>
                  <idno type="halauthorid">707068-0</idno>
                  <affiliation ref="#struct-480402"/>
                  <affiliation ref="#struct-300093"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <idno type="eissn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">0160990</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0160990</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Neonates</term>
                <term xml:lang="en">Creatine</term>
                <term xml:lang="en">Central nervous system</term>
                <term xml:lang="en">Macromolecules</term>
                <term xml:lang="en">Magnetic resonance imaging</term>
                <term xml:lang="en">Metabolites</term>
                <term xml:lang="en">Magnetic resonance spectroscopy</term>
                <term xml:lang="en">Glutamate</term>
                <term xml:lang="en">Neonates</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.ib.ima">Life Sciences [q-bio]/Bioengineering/Imaging</classCode>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Preterm birth represents a high risk of neurodevelopmental disabilities when associated with white-matter damage. Recent studies have reported cognitive deficits in children born preterm without brain injury on MRI at term-equivalent age. Understanding the microstruc-tural and metabolic underpinnings of these deficits is essential for their early detection. Here, we used diffusion-weighted imaging and single-voxel 1 H magnetic resonance spec-troscopy (MRS) to compare brain maturation at term-equivalent age in premature neonates with no evidence of white matter injury on conventional MRI except diffuse excessive high-signal intensity, and normal term neonates. Thirty-two infants, 16 term neonates (mean post-conceptional age at scan: 39.8±1 weeks) and 16 premature neonates (mean gesta-tional age at birth: 29.1±2 weeks, mean post-conceptional age at scan: 39.2±1 weeks) were investigated. The MRI/MRS protocol performed at 1.5T involved diffusion-weighted MRI and localized 1 H-MRS with the Point RESolved Spectroscopy (PRESS) sequence. Preterm neonates showed significantly higher ADC values in the temporal white matter (P&amp;lt;0.05), the occipital white matter (P&amp;lt;0.005) and the thalamus (P&amp;lt;0.05). The proton spectrum of the centrum semiovale was characterized by significantly lower taurine/H 2 O and macromole-cules/H 2 O ratios (P&amp;lt;0.05) at a TE of 30 ms, and reduced (creatine+phosphocreatine)/H 2 O and (glutamine+glutamate)/H 2 O ratios (P&amp;lt;0.05) at a TE of 135 ms in the preterm neonates than in full-term neonates. Our findings indicate that premature neonates with normal conventional MRI present a delay in brain maturation affecting the white matter and the thala-mus. Their brain metabolic profile is characterized by lower levels of creatine, glutamine plus glutamate, and macromolecules in the centrum semiovale, a finding suggesting altered energy metabolism and protein synthesis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-217648" status="VALID">
          <idno type="IdRef">176969721</idno>
          <idno type="RNSR">201320497C</idno>
          <idno type="ROR">https://ror.org/00k4e5n71</idno>
          <idno type="Wikidata">Q30262162</idno>
          <orgName>Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie</orgName>
          <orgName type="acronym">ICube</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>300 bd Sébastien Brant - BP 10413 - F-67412 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://icube.unistra.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-94023" type="direct"/>
            <relation active="#struct-199013" type="direct"/>
            <relation active="#struct-211628" type="direct"/>
            <relation active="#struct-261615" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation name="UMR7357" active="#struct-441569" type="direct"/>
            <relation active="#struct-529627" type="direct"/>
            <relation name="FR3627" active="#struct-199013" type="direct"/>
            <relation active="#struct-237692" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation name="FR3627" active="#struct-441569" type="direct"/>
            <relation active="#struct-529628" type="direct"/>
            <relation name="FR3678" active="#struct-199013" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-186337" status="VALID">
          <orgName>Service de radiologie [Strasbourg]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300149" type="direct"/>
            <relation active="#struct-211628" type="indirect"/>
            <relation active="#struct-357391" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-480402" status="VALID">
          <idno type="IdRef">122901924</idno>
          <idno type="RNSR">201220246J</idno>
          <idno type="ROR">https://ror.org/04ceg1205</idno>
          <orgName>Centre de résonance magnétique biologique et médicale</orgName>
          <orgName type="acronym">CRMBM</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine27 Bd Jean Moulin 13385 MARSEILLE CEDEX 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crmbm.univ-amu.fr/?lang=fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR7339" active="#struct-198056" type="direct"/>
            <relation name="UMR7339" active="#struct-300073" type="direct"/>
            <relation name="UMR7339" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-530749" status="VALID">
          <orgName>RMN et optique : De la mesure au biomarqueur</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-139739" type="direct"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-219748" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1206" active="#struct-303623" type="indirect"/>
            <relation name="UMR5220" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-94023" status="VALID">
          <idno type="ROR">https://ror.org/02jhjzd11</idno>
          <orgName>École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg</orgName>
          <orgName type="acronym">ENGEES</orgName>
          <desc>
            <address>
              <addrLine>1 quai Koch - BP 61039 - 67070 Strasbourg Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://engees.unistra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-211628" status="VALID">
          <idno type="IdRef">030378842</idno>
          <idno type="ROR">https://ror.org/04bckew43</idno>
          <orgName>Hôpitaux Universitaires de Strasbourg</orgName>
          <orgName type="acronym">HUS</orgName>
          <desc>
            <address>
              <addrLine>1 place de l'hôpital BP 426 67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-261615" status="VALID">
          <orgName>Institut National des Sciences Appliquées - Strasbourg</orgName>
          <orgName type="acronym">INSA Strasbourg</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-strasbourg.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-529627" status="VALID">
          <idno type="RNSR">201420878M</idno>
          <orgName>Matériaux et Nanosciences Grand-Est</orgName>
          <orgName type="acronym">MNGE</orgName>
          <date type="start">2014-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="FR3627" active="#struct-199013" type="direct"/>
            <relation active="#struct-237692" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="FR3627" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-237692" status="VALID">
          <idno type="IdRef">026403250</idno>
          <idno type="ISNI">0000000404735039</idno>
          <idno type="ROR">https://ror.org/04k8k6n84</idno>
          <orgName>Université de Haute-Alsace (UHA) Mulhouse - Colmar</orgName>
          <orgName type="acronym">Université de Haute-Alsace (UHA)</orgName>
          <desc>
            <address>
              <addrLine>2, rue des Frères Lumière F-68093 Mulhouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uha.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-529628" status="VALID">
          <orgName>Réseau nanophotonique et optique</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="FR3678" active="#struct-199013" type="direct"/>
            <relation active="#struct-237692" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300149" status="VALID">
          <orgName>Centre Hospitalier Universitaire [Strasbourg]</orgName>
          <orgName type="acronym">CHU Strasbourg</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-211628" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-357391" status="VALID">
          <idno type="ROR">https://ror.org/04e1w6923</idno>
          <orgName>Hôpital de Hautepierre [Strasbourg]</orgName>
          <desc>
            <address>
              <addrLine>Avenue Molière67200 Strasbourg</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-strasbourg.fr/Hopital-de-Hautepierre</ref>
          </desc>
          <listRelation>
            <relation active="#struct-211628" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-139739" status="VALID">
          <idno type="IdRef">19513270X</idno>
          <idno type="ISNI">0000000406380358</idno>
          <idno type="RNSR">200717526Z</idno>
          <idno type="ROR">https://ror.org/03smk3872</idno>
          <orgName>Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</orgName>
          <orgName type="acronym">CREATIS</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>7 avenue Jean Capelle, Bat Blaise Pascal, 69621 Villeurbanne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.creatis.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1206" active="#struct-303623" type="direct"/>
            <relation name="UMR5220" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>