Resistant depression : Switching and combining strategies of ă antidepressant medications - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue La Presse Médicale Année : 2016

Resistant depression : Switching and combining strategies of ă antidepressant medications

Fanny Moliere
  • Fonction : Auteur
Frederic Haesebaert
  • Fonction : Auteur
Remy Bation
  • Fonction : Auteur
Isabel Nieto
  • Fonction : Auteur
Frank Bellivier
Jerome Holtzmann
  • Fonction : Auteur
Vincent Camus
Olivier Doumy
  • Fonction : Auteur
Marion Garnier
  • Fonction : Auteur
Pierre-Michel Llorca
Guillaume Vaiva

Résumé

Switching antidepressant medication may be helpful in depressed patients ă having no benefit from the initial antidepressant treatment. ă Before considering switching strategy, the initial antidepressant ă treatment should produce no therapeutic effect after at least 4 weeks of ă administration at adequate dosage. ă Choosing an antidepressant of pharmacologically distinct profile fails ă to consistently demonstrate a significant superiority in terms of ă effectiveness over the switching to another antidepressant within the ă same pharmacological class. ă Augmenting SSRI/SNRIs with mirtazapine/mianserin has become the most ă recommended strategy of antidepressant combinations. ă Augmenting SSRI with tricyclic drugs is now a less recommended strategy ă of antidepressant combinations given the increased risk for the ă occurrence of pharmacokinetic drug-drug interactions and adverse ă effects.
Fichier non déposé

Dates et versions

hal-01482632 , version 1 (03-03-2017)

Identifiants

Citer

Thomas Charpeaud, Fanny Moliere, Maxime Bubrovszky, Frederic Haesebaert, Najib Allaïli, et al.. Resistant depression : Switching and combining strategies of ă antidepressant medications. La Presse Médicale, 2016, 45 (3), pp.329-337. ⟨10.1016/j.lpm.2016.02.003⟩. ⟨hal-01482632⟩
554 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More