The assessment of co-existing psychological and psychiatric disorders is ă advocated in the Standards of Care for the health of transsexual people. ă This study aimed to determine the psychopathological characteristics of ă transsexuals based on a large sample of French individuals and to ă identify whether these characteristics differed according to the ă individual's sociodemographic or clinical characteristics. The aim of ă this study was to determine the psychopathological characteristics of ă transsexuals from a large sample of French individuals and whether these ă differed by sociodemographic or clinical characteristics. This ă cross-sectional study was conducted in a French public university ă hospital. The inclusion criteria were 18 years or older, diagnosis of ă gender dysphoria, and eligibility for a standardized sex reassignment ă procedure. Personality characteristics were assessed using the Minnesota ă Multiphasic Personality Inventory 2 (MMPI-2). A total of 108 individuals ă provided a valid MMPI-2 between January 2007 and December 2010. The ă final sample had a median age of 31 years and included 54 (50%) ă Female-to-Male individuals. In multivariate models, hormonal therapy ă status was significantly related to the scales of MMPI-2 (Psychasthenia ă and Masculinity/Femininity). Personality assessment can help a ă multidisciplinary gender dysphoria team detect potential ă psychopathological factors of vulnerability.