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                <title xml:lang="en">Treatment failure following excision therapy of CIN: the impact of ă direct colposcopic vision during procedure</title>
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              <p>To assess whether the use of direct colposcopic vision during excision ă therapy of cervical intraepithelial neoplasia (CIN) has an impact on the ă risk of treatment failure. ă Data from 285 patients who had had excision therapy with proven CIN at ă specimen histological analysis were reviewed. Primary endpoint was the ă occurrence of post-treatment failure defined by the histological ă diagnosis of CIN 2-3 during follow-up. Data were analysed according to ă the use of colposcopy at the time of initial therapy of CIN. ă The use of direct colposcopic vision (DCV) resulted in a significant ă reduction in the mean height (p = 0.008) and diameter (p &lt; 0.001) of the ă excised specimen. Patients' median follow-up was 28.4 (+/- 1.3) months. ă A total of 43 (15.2 %) patients were diagnosed with treatment failure. ă Compared to excisions performed without any use of colposcopy, DCV was ă not found to have any significant impact on the risk of treatment ă failure (HR: 0.58; 95 % CI 0.16-2.13, p = 0.412), neither when compared ă to excisions performed immediately after colposcopy (HR: 0.91; 95 % CI ă 0.47-1.79; p = 0.794). The only factors found to have a significant ă impact on the risk of treatment failure was the identification of clear ă margins (HR: 0.36; 95 %CI 0.19-0.69; p = 0.002) and the diameter of the ă surgical specimen (HR: 0.94; 95 %CI 0.89-0.99; p = 0.040). ă Although the use of DCV during excision therapy of CIN was associated ă with a significant reduction in the dimensions of the excised cervical ă specimen, it did not result in a significant change in the risk of ă treatment failure.</p>
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            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
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        <org type="institution" xml:id="struct-301315" status="VALID">
          <idno type="ISNI">0000 0001 0304 0719 </idno>
          <idno type="ROR">https://ror.org/029a4pp87</idno>
          <orgName>Hôpital Nord [CHU - APHM]</orgName>
          <date type="start">1964</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord - Chemin des Bourrely13915Marseille cedex 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-nord</ref>
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        <org type="institution" xml:id="struct-195507" status="VALID">
          <idno type="ROR">https://ror.org/00mfpxb84</idno>
          <orgName>Avignon Université</orgName>
          <orgName type="acronym">AU</orgName>
          <desc>
            <address>
              <addrLine>74 rue Louis Pasteur - 84 029 Avignon cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-avignon.fr/</ref>
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        <org type="institution" xml:id="struct-302715" status="VALID">
          <orgName>Institut de recherche pour le développement [IRD] : UMR237</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
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        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
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            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
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