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Article Dans Une Revue Psychiatry Research: Neuroimaging Année : 2016

Functional brain substrate of quality of life in patients with ă schizophrenia: A brain SPECT multidimensional analysis

Résumé

The aim of this study was to investigate the functional brain substrate ă of quality of life (QoL) in patients with schizophrenia. Participants ă comprised 130 right-handed patients with schizophrenia who underwent ă whole-brain single photon emission computed tomography (SPECT) with ă Tc-99m-labeled ethylcysteinate dimer (Tc-99m-ECD) for exploring ă correlations of regional cerebral blood flow (rCBF) with the eight ă dimensions score of the Schizophrenia Quality of Life questionnaire ă (S-QoL 18). A significant positive correlation was found between the ă global index of the S-QoL 18 and rCBF in the right superior temporal ă sulcus and between psychological well-being dimension and rCBF in ă Brodmann area (BA)6, BA8, BA9, and BA10 and between self-esteem ă dimension and rCBF in striatum and between family relationship dimension ă and rCBF in BA1, BA2, BA3, BA4, BA8, BA22, BA40, BA42 and BA44 and ă between relationship with friends dimension and rCBF in BA44 and between ă physical well-being dimension and rCBF in parahippocampal gyrus, and ă finally between autonomy dimension and rCBF in cuneus and precuneus. A ă significant negative correlation was found between resilience dimension ă and rCBF in precuneus and between sentimental life dimension and rCBF in ă BA10. Our findings provide neural correlates of QoL. Brain regions ă involved in cognitions, emotional information processing and social ă cognition underlie the different QoL dimensions. (C) 2016 Published by ă Elsevier Ireland Ltd.
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hal-01482504 , version 1 (03-03-2017)

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Catherine Faget-Agius, Laurent Boyer, Raphaëlle Richieri, Pascal Auquier, Christophe Lançon, et al.. Functional brain substrate of quality of life in patients with ă schizophrenia: A brain SPECT multidimensional analysis. Psychiatry Research: Neuroimaging, 2016, 249, pp.67-75. ⟨10.1016/j.pscychresns.2016.02.005⟩. ⟨hal-01482504⟩
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