Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.

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OS ARTICULATION HUMAINE

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Biomécanique [physics.med-ph]

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https://hal.science/hal-01464943

Soumis le : mercredi 22 février 2017-11:21:52

Dernière modification le : vendredi 20 décembre 2024-16:22:03

Archivage à long terme le : mardi 23 mai 2017-13:23:36

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hal-01464943 , version 1 (22-02-2017)

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HAL Id : hal-01464943 , version 1
DOI : 10.1128/AAC.02597-15

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Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, et al.. Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections. Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp. 3148-3151. ⟨10.1128/AAC.02597-15⟩. ⟨hal-01464943⟩

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