<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01464091</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T05:07:07+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Is tryptophan metabolism involved in sleep apnea-related cardiovascular co-morbidities and cancer progression?</title>
            <author role="aut">
              <persName>
                <forename type="first">Lysiane</forename>
                <surname>Boulet</surname>
              </persName>
              <idno type="halauthorid">1130652-0</idno>
              <affiliation ref="#struct-11960"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrice</forename>
                <surname>Flore</surname>
              </persName>
              <idno type="halauthorid">395778-0</idno>
              <affiliation ref="#struct-11960"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Le Gouellec</surname>
              </persName>
              <email type="md5">a8ca1e1429fc31459c02308fdec481f3</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="string">sc-legouellec</idno>
              <idno type="idhal" notation="numeric">1219109</idno>
              <idno type="halauthorid" notation="string">17873-1219109</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAC-3013-2019</idno>
              <idno type="IDREF">https://www.idref.fr/134039823</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4905-3854</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAC-3013-2019</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B</forename>
                <surname>Toussaint</surname>
              </persName>
              <idno type="halauthorid">642610-0</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean Louis</forename>
                <surname>Pépin</surname>
              </persName>
              <email type="md5">7e53db0b5e46541c887d77e2e417c5c7</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">760683</idno>
              <idno type="halauthorid" notation="string">1130653-760683</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3832-2358</idno>
              <idno type="IDREF">https://www.idref.fr/110689410</idno>
              <affiliation ref="#struct-250436"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P</forename>
                <surname>Faure</surname>
              </persName>
              <email type="md5">c212aaee5aa64a55e21ce0716c4ec0c0</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">870588</idno>
              <idno type="halauthorid" notation="string">770799-870588</idno>
              <idno type="IDREF">https://www.idref.fr/060963190</idno>
              <idno type="ISNI">http://isni.org/isni/0000000441600424</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0963-6932</idno>
              <idno type="VIAF">https://viaf.org/viaf/216064054</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7139-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/EYK-7429-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7139-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EYK-7429-2022</idno>
              <affiliation ref="#struct-11960"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Audrey</forename>
                <surname>Le Gouellec</surname>
              </persName>
              <email type="md5">a8ca1e1429fc31459c02308fdec481f3</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-02-09 22:13:01</date>
              <date type="whenModified">2025-09-27 18:32:36</date>
              <date type="whenReleased">2017-02-09 22:13:01</date>
              <date type="whenProduced">2015-07-02</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-DW3SHG1R-4/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="77640">
                <persName>
                  <forename>Audrey</forename>
                  <surname>Le Gouellec</surname>
                </persName>
                <email type="md5">a8ca1e1429fc31459c02308fdec481f3</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01464091</idno>
            <idno type="halUri">https://hal.science/hal-01464091</idno>
            <idno type="halBibtex">boulet:hal-01464091</idno>
            <idno type="halRefHtml">&lt;i&gt;Medical Hypotheses&lt;/i&gt;, 2015, pp.415-23. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.mehy.2015.06.022"&gt;&amp;#x27E8;10.1016/j.mehy.2015.06.022&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Medical Hypotheses, 2015, pp.415-23. &amp;#x27E8;10.1016/j.mehy.2015.06.022&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEREX" corresp="TIMC-IMAG">TheREx : Thérapeutique Recombinante Expérimentale</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Is tryptophan metabolism involved in sleep apnea-related cardiovascular co-morbidities and cancer progression?</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Lysiane</forename>
                    <surname>Boulet</surname>
                  </persName>
                  <idno type="halauthorid">1130652-0</idno>
                  <affiliation ref="#struct-11960"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrice</forename>
                    <surname>Flore</surname>
                  </persName>
                  <idno type="halauthorid">395778-0</idno>
                  <affiliation ref="#struct-11960"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Le Gouellec</surname>
                  </persName>
                  <email type="md5">a8ca1e1429fc31459c02308fdec481f3</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="string">sc-legouellec</idno>
                  <idno type="idhal" notation="numeric">1219109</idno>
                  <idno type="halauthorid" notation="string">17873-1219109</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAC-3013-2019</idno>
                  <idno type="IDREF">https://www.idref.fr/134039823</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4905-3854</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAC-3013-2019</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B</forename>
                    <surname>Toussaint</surname>
                  </persName>
                  <idno type="halauthorid">642610-0</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean Louis</forename>
                    <surname>Pépin</surname>
                  </persName>
                  <email type="md5">7e53db0b5e46541c887d77e2e417c5c7</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">760683</idno>
                  <idno type="halauthorid" notation="string">1130653-760683</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3832-2358</idno>
                  <idno type="IDREF">https://www.idref.fr/110689410</idno>
                  <affiliation ref="#struct-250436"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P</forename>
                    <surname>Faure</surname>
                  </persName>
                  <email type="md5">c212aaee5aa64a55e21ce0716c4ec0c0</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">870588</idno>
                  <idno type="halauthorid" notation="string">770799-870588</idno>
                  <idno type="IDREF">https://www.idref.fr/060963190</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000441600424</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0963-6932</idno>
                  <idno type="VIAF">https://viaf.org/viaf/216064054</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7139-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/EYK-7429-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7139-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EYK-7429-2022</idno>
                  <affiliation ref="#struct-11960"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">16986</idno>
                <idno type="issn">0306-9877</idno>
                <title level="j">Medical Hypotheses</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="pp">415-23</biblScope>
                  <date type="datePub">2015-07-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.mehy.2015.06.022</idno>
              <idno type="pubmed">26182975</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Hypoxia</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Models, Theoretical</classCode>
              <classCode scheme="mesh">Neoplasms</classCode>
              <classCode scheme="mesh">Obesity</classCode>
              <classCode scheme="mesh">Rats</classCode>
              <classCode scheme="mesh">Risk Factors</classCode>
              <classCode scheme="mesh">Sleep Apnea, Obstructive</classCode>
              <classCode scheme="mesh">Tryptophan</classCode>
              <classCode scheme="mesh">Cardiovascular Diseases</classCode>
              <classCode scheme="mesh">Comorbidity</classCode>
              <classCode scheme="mesh">Disease Progression</classCode>
              <classCode scheme="mesh">Heme</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Obstructive sleep apnea (OSA) is a multi-component chronic disease affecting 6-17% of adults in the general population. The main hallmark of OSA, intermittent hypoxia (IH), is reported as the main trigger for cardiometabolic co-morbidities. Recent studies, both in rodent models exposed to IH and in humans, have suggested an enhanced incidence and accelerated progression of cancer. However, mechanisms underlying the relationships between OSA and cardiovascular disease on one hand, and cancer on the other hand, have not been entirely deciphered yet. Tryptophan (TRP) metabolism results in nicotinamid and serotonin production, but also in the production of numerous intermediates such as kynurenine, anthranilic and kynurenic acids, 3-hydroxykynurenine, 3-hydroxyanthranilic and quinolinic acids. Each of these metabolites has been linked to cardiovascular disease and cancer mainly in epidemiologic studies. We hypothesize that an alteration of TRP metabolism may play a role in OSA-related cardiovascular co-morbidities and might be one of the players in the relationship between cancer and intermittent hypoxia/OSA. If this is true, interventions aiming to modify TRP metabolism, may constitute a new therapeutic strategy against cardiovascular disease progression and cancer occurrence in OSA populations.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-11960" status="OLD">
          <idno type="IdRef">18493902X</idno>
          <idno type="RNSR">201119418N</idno>
          <orgName>Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire</orgName>
          <orgName type="acronym">HP2</orgName>
          <date type="start">2002-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Facultés de médecine et de pharmacie Domaine de la merci 38706 LA TRONCHE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hp2.univ-grenoble-alpes.fr/accueil</ref>
          </desc>
          <listRelation>
            <relation name="EA3745 / ERI17" active="#struct-51016" type="direct"/>
            <relation name="U1042" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388270" status="INCOMING">
          <orgName>TheREx</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-250436" status="INCOMING">
          <orgName>Observatoire régional de la santé</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-359798" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-359798" status="INCOMING">
          <orgName>Observatoire régional de la santé</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>