High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
Résumé
We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl) phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthy len-1(2H)-one from the reactions of 4-[4-(chloromethyl) phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and alpha-carbonyl ester derivatives using tetrakis(dimethylamino) ethylene (TDAE) methodology.
Domaines
Chimie organique| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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