<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01460127</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T05:13:38+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis</title>
            <author role="aut">
              <persName>
                <forename type="first">Raoul</forename>
                <surname>Belzeaux</surname>
              </persName>
              <email type="md5">d7ca33947cd2c632cb5c468a6314039f</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">774517</idno>
              <idno type="halauthorid" notation="string">926357-774517</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1222-6050</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=gOo7GZgAAAAJ</idno>
              <idno type="IDREF">https://www.idref.fr/119707683</idno>
              <idno type="VIAF">https://viaf.org/viaf/212065053</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139616329</idno>
              <affiliation ref="#struct-192792"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chien-Wei</forename>
                <surname>Lin</surname>
              </persName>
              <idno type="halauthorid">1128046-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ying</forename>
                <surname>Ding</surname>
              </persName>
              <idno type="halauthorid">707295-0</idno>
              <affiliation ref="#struct-490478"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurélie</forename>
                <surname>Bergon</surname>
              </persName>
              <email type="md5">cfaf0023c3fb298819878866b02e2838</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">aurelie-bergon</idno>
              <idno type="idhal" notation="numeric">11718</idno>
              <idno type="halauthorid" notation="string">20201-11718</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1518-4562</idno>
              <idno type="IDREF">https://www.idref.fr/169232905</idno>
              <affiliation ref="#struct-182200"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">El Chérif</forename>
                <surname>Ibrahim</surname>
              </persName>
              <email type="md5">a2388247ce25583c3bdaa8ead4f28894</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">el-cherif-ibrahim</idno>
              <idno type="idhal" notation="numeric">1001198</idno>
              <idno type="halauthorid" notation="string">162396-1001198</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=AVbxFLAAAAAJ</idno>
              <affiliation ref="#struct-192792"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gustavo</forename>
                <surname>Turecki</surname>
              </persName>
              <idno type="idhal" notation="numeric">769354</idno>
              <idno type="halauthorid" notation="string">735266-769354</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4075-2736</idno>
              <affiliation ref="#struct-47878"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">George</forename>
                <surname>Tseng</surname>
              </persName>
              <idno type="halauthorid">1128047-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Etienne</forename>
                <surname>Sibille</surname>
              </persName>
              <idno type="halauthorid">1128048-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Lionel</forename>
                <surname>Spinelli</surname>
              </persName>
              <email type="md5">d8353075f6f87cbc36318c2e46bbb887</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-02-07 16:00:17</date>
              <date type="whenModified">2025-01-06 16:32:02</date>
              <date type="whenReleased">2017-02-07 16:00:17</date>
              <date type="whenProduced">2016-10</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="469963">
                <persName>
                  <forename>Lionel</forename>
                  <surname>Spinelli</surname>
                </persName>
                <email type="md5">d8353075f6f87cbc36318c2e46bbb887</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01460127</idno>
            <idno type="halUri">https://amu.hal.science/hal-01460127</idno>
            <idno type="halBibtex">belzeaux:hal-01460127</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Psychiatric Research&lt;/i&gt;, 2016, 81, pp.119-126. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.jpsychires.2016.07.009"&gt;&amp;#x27E8;10.1016/j.jpsychires.2016.07.009&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Psychiatric Research, 2016, 81, pp.119-126. &amp;#x27E8;10.1016/j.jpsychires.2016.07.009&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="TAGC">Technologies avancées pour le génôme et la clinique</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Raoul</forename>
                    <surname>Belzeaux</surname>
                  </persName>
                  <email type="md5">d7ca33947cd2c632cb5c468a6314039f</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">774517</idno>
                  <idno type="halauthorid" notation="string">926357-774517</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1222-6050</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=gOo7GZgAAAAJ</idno>
                  <idno type="IDREF">https://www.idref.fr/119707683</idno>
                  <idno type="VIAF">https://viaf.org/viaf/212065053</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139616329</idno>
                  <affiliation ref="#struct-192792"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chien-Wei</forename>
                    <surname>Lin</surname>
                  </persName>
                  <idno type="halauthorid">1128046-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ying</forename>
                    <surname>Ding</surname>
                  </persName>
                  <idno type="halauthorid">707295-0</idno>
                  <affiliation ref="#struct-490478"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurélie</forename>
                    <surname>Bergon</surname>
                  </persName>
                  <email type="md5">cfaf0023c3fb298819878866b02e2838</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">aurelie-bergon</idno>
                  <idno type="idhal" notation="numeric">11718</idno>
                  <idno type="halauthorid" notation="string">20201-11718</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1518-4562</idno>
                  <idno type="IDREF">https://www.idref.fr/169232905</idno>
                  <affiliation ref="#struct-182200"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">El Chérif</forename>
                    <surname>Ibrahim</surname>
                  </persName>
                  <email type="md5">a2388247ce25583c3bdaa8ead4f28894</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">el-cherif-ibrahim</idno>
                  <idno type="idhal" notation="numeric">1001198</idno>
                  <idno type="halauthorid" notation="string">162396-1001198</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=AVbxFLAAAAAJ</idno>
                  <affiliation ref="#struct-192792"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gustavo</forename>
                    <surname>Turecki</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">769354</idno>
                  <idno type="halauthorid" notation="string">735266-769354</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4075-2736</idno>
                  <affiliation ref="#struct-47878"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">George</forename>
                    <surname>Tseng</surname>
                  </persName>
                  <idno type="halauthorid">1128047-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Etienne</forename>
                    <surname>Sibille</surname>
                  </persName>
                  <idno type="halauthorid">1128048-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">16097</idno>
                <idno type="issn">0022-3956</idno>
                <idno type="eissn">1879-1379</idno>
                <title level="j">Journal of Psychiatric Research</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">81</biblScope>
                  <biblScope unit="pp">119-126</biblScope>
                  <date type="datePub">2016-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.jpsychires.2016.07.009</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Antidepressant efficacy is insufficient, unpredictable and poorly understood in major depressive episode (MDE). Gene expression studies allow for the identification of significantly dysregulated genes but can limit the exploration of biological pathways. In the present study, we proposed a gene coexpression analysis to investigate biological pathways associated with treatment response predisposition and their regulation by microRNAs (miRNAs) in peripheral blood samples of MDE and healthy control subjects. We used a discovery cohort that included 34 MDE patients that were given 12-week treatment with citalopram and 33 healthy controls. Two replication cohorts with similar design were also analyzed. Expression-based gene network was built to define clusters of highly correlated sets of genes, called modules. Association between each module's first principal component of the expression data and clinical improvement was tested in the three cohorts. We conducted gene ontology analysis and miRNA prediction based on the module gene list. Nine of the 59 modules from the gene coexpression network were associated with clinical improvement. The association was partially replicated in other cohorts. Gene ontology analysis demonstrated that 4 modules were associated with cytokine production, acute inflammatory response or IL-8 functions. Finally, we found 414 miRNAs that may regulate one or several modules associated with clinical improvement. By contrast, only 12 miRNAs were predicted to specifically regulate modules unrelated to clinical improvement. Our gene coexpression analysis underlines the importance of inflammation-related pathways and the involvement of a large miRNA program as biological processes predisposing associated with antidepressant response. (C) 2016 Elsevier Ltd. All rights reserved.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-192792" status="OLD">
          <idno type="IdRef">141380888</idno>
          <idno type="RNSR">201220261A</idno>
          <orgName>Centre de recherche en neurobiologie - neurophysiologie de Marseille</orgName>
          <orgName type="acronym">CRN2M</orgName>
          <date type="start">2012</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Secteur Nord Boulevard Pierre Dramard 13916 MARSEILLE CEDEX 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crn2m.univ-mrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR7286" active="#struct-198056" type="direct"/>
            <relation name="UMR7286" active="#struct-303623" type="direct"/>
            <relation name="UMR7286" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-490478" status="VALID">
          <idno type="ROR">https://ror.org/054pv6659</idno>
          <orgName>Leopold Franzens Universität Innsbruck - University of Innsbruck</orgName>
          <desc>
            <address>
              <addrLine>Innrain 52, A-6020 Innsbruck</addrLine>
              <country key="AT"/>
            </address>
            <ref type="url">https://www.uibk.ac.at/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-182200" status="OLD">
          <idno type="IdRef">151384134</idno>
          <idno type="RNSR">201220169A</idno>
          <orgName>Technologies avancées pour le génôme et la clinique</orgName>
          <orgName type="acronym">TAGC</orgName>
          <date type="start">2012</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://tagc.univ-mrs.fr/tagc/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation name="U1090" active="#struct-303623" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-47878" status="VALID">
          <orgName>Department of Psychiatry [Montréal]</orgName>
          <desc>
            <address>
              <addrLine>Ludmer Research &amp; Training Building1033 Pine Avenue WestMontreal, QC, H3A 1A1</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">https://www.mcgill.ca/psychiatry/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-134741" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-134741" status="VALID">
          <idno type="ROR">https://ror.org/01pxwe438</idno>
          <orgName>McGill University = Université McGill [Montréal, Canada]</orgName>
          <desc>
            <address>
              <addrLine>845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">http://www.mcgill.ca/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>