In the domain of digital wireless communication, flexible design implementations are increasingly explored for different applications in order to cope with diverse system configurations imposed by the emerging wireless communication standards. In fact, shrinking the design time to meet market pressure, on the one hand, and adding the emerging flexibility requirement and, hence, increasing system complexity, on the other hand, require a productive design approach that also ensures final design quality. The no instruction set computer (NISC) approach fulfills these design requirements by eliminating the instruction set overhead. The approach offers static scheduling of the datapath, automated register transfer language (RTL)synthesis and allows the designer to have direct control of hardware resources. This paper presents a complete NISC-based design and prototype flow, from architecture specification till FPGA implementation. The proposed design and prototype flow is illustrated through two case studies of flexible implementations, which are dedicated to low-complexity MIMO turbo-equalizer and a universal turbo-demapper. Moreover, the flexibility of the proposed prototypes allows supporting all communication modes defined in the emerging wireless communication standards, such LTE, LTE-Advanced, WiMAX, WiFi and DVB-RCS. For each prototype, its functionality is evaluated, and the resultant performance is verified for all system configurations.