We report the results of a large-scale picture naming experiment in which we evaluated the potential contribution of nine theoretically relevant factors to naming latencies. The experiment included a large number of items and a large sample of participants. In order to make this experiment as similar as possible to classic picture naming experiments, participants were familiarized with the materials during a training session. Speeded naming latencies were determined by a software key on the basis of the digital recording of the responses. The effects of various variables on these latencies were assessed with multiple regression techniques, using a repeated measures design. The interpretation of the observed effects is discussed in relation to previous studies and current views on lexical access during speech production.