Glycan complexity dictates microbial resource allocation in the large intestine - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2015

Glycan complexity dictates microbial resource allocation in the large intestine

Résumé

The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota.
Fichier principal
Vignette du fichier
ncomms8481.pdf (1.96 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01439017 , version 1 (07-01-2020)

Licence

Paternité

Identifiants

Citer

Artur Rogowski, Jonathon A. Briggs, Jennifer C. Mortimer, Theodora Tryfona, Nicolas Terrapon, et al.. Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications, 2015, 6, ⟨10.1038/ncomms8481⟩. ⟨hal-01439017⟩
436 Consultations
39 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More