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Article Dans Une Revue FEBS Letters Année : 2015

Desulfovibrio desulfuricans isolates from the gut of a single individual: structural and biological lipid A characterization.

Résumé

The levels of sulfate-reducing bacteria (SRB), including Desulfovibrionaceae, in the gut increase following a fat-enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae lipopolysaccharides (LPS) that are associated with the microbiota inflammatory properties. LPS variants were obtained from two SRB isolates from the gut of a single individual. These LPS variants shared similar lipid A moieties with Enterobacterial LPS, but differed from one another with regard to fatty-acid numbers and endotoxic activity. This first complete structural characterization of Desulfovibrio lipid A gives new insights into previously published data on Desulfovibrio lipid A biosynthesis. LPS microdiversity within SRBs illustrates how adaptation can influence pro-inflammatory potential.

Dates et versions

hal-01436243 , version 1 (16-01-2017)

Identifiants

Citer

Wei Zhang-Sun, Luis A Augusto, Liping Zhao, Martine Caroff. Desulfovibrio desulfuricans isolates from the gut of a single individual: structural and biological lipid A characterization.. FEBS Letters, 2015, 589 (1), pp.165-71. ⟨10.1016/j.febslet.2014.11.042⟩. ⟨hal-01436243⟩
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