This chapter deals with the application of Model-Driven approaches in a Technology Enhanced Learning (TEL) context. Such Software Engineering approaches can provide some concrete benefits. Because computer scientists or engineers cannot currently find well-defined frameworks about this new trend, we have chosen to report recent results of our working group (initiated in 2003) in order to provide reader with a survival kit. Our results showed that Model Driven Engineering can help designers to reduce the gap between specific instructional requirements (domain point of view) and the software architectures that concretely support the implementation, the runtime and the regulation of this instruction