Inflammatory bowel diseases (IBD) increase the risk of developing colorectal cancer (CRC) [1]. The abnormal proliferation of cells induces subsurface anatomical and biochemical changes that cannot be early assessed with conventional modalities. Proton magnetic resonance spectroscopy (MRS) has been shown to have clinical value in managing cancers of the brain, breast, prostate, and it may be useful for the diagnosis and monitoring of IBD. Up to now, there have been no reports of the in vivo assessment of colon walls using MRS. In this work, dedicated endorectal coils (EC) [2] which locally improve significantly SNR were used to carry out MRS in small voxel without time penalties or SNR issues for the characterization of colorectal tumors on a mouse model of colitis [3].