Moesin expression is a marker of basal breast carcinomas - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Cancer Année : 2007

Moesin expression is a marker of basal breast carcinomas

Résumé

Basal breast cancers (BBCs) have a high risk of metastasis, recurrence and death. Formal subtype definition relies on gene expression but can be approximated by protein expression. New markers are needed to help in the management of the basal subtype of breast cancer. In a previous transcriptional analysis of breast cell lines we found that Moesin expression was a potential basal marker. We show here that Moesin protein expression is a basal marker in breast tumors. In a tissue microarray (TMA) containing 547 sporadic breast cancers, of which 108 were profiled for gene expression, Moesin was expressed in 31% of all tumors and in 82% of the basal tumors. To confirm that Moesin expression remained associated with the basal phenotype in specific types of BBCs, we analyzed Moesin expression in 2 other TMAs containing 40 medullary breast cancers (MBCs) and 27 BRCA1 -associated breast cancers (BRCA1-BCs), respectively. Moesin was strongly expressed in MBCs 87%; p = 2.4 x 10(-5)) and in BRCA1-BCs (58%; p = 1.3 x 10(-5)) as compared with non-MBCs and sporadic cases. Moesin-expressing tumors display features of BBCs, such as high proliferation rate, hormone receptors negativity, expression of putative basal/myoepithelial markers (CAVI, CD10, CK5/6, CK14, EGFR, P53, P-cadherin and SMA). Survival analysis showed a reduced specific survival and metastasis-free survival in Moesin-expressing tumors by log-rank test (p(SS) = 0.014 and P(MFS) = 0.014). In multivariate analysis, Moesin expression was nearly an independent prognostic marker of poor outcome as shown by Cox proportional hazard model in patients without lymph node metastasis (p = 0.052, HR = 2.38, CI 95[0.99-5.69]). (C) 2007 Wiley-Liss, Inc.
Fichier non déposé

Dates et versions

hal-01431969 , version 1 (11-01-2017)

Identifiants

Citer

Emmanuelle Charafe-Jauffret, Florence Monville, Francois Bertucci', Benjamin Esterni, Christophe Ginestier, et al.. Moesin expression is a marker of basal breast carcinomas. International Journal of Cancer, 2007, 121 (8), pp.1779-1785. ⟨10.1002/ijc.22923⟩. ⟨hal-01431969⟩

Collections

INSERM UNIV-AMU
45 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More