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Article Dans Une Revue Cell Cycle Année : 2009

Retinoid signaling regulates breast cancer stem cell differentiation

Résumé

The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.

Dates et versions

hal-01431955 , version 1 (11-01-2017)

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Christophe Ginestier, Julien Wicinski, Nathalie Cervera, Florence Monville, Pascal Finetti, et al.. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle, 2009, 8 (20), pp.3297-3302. ⟨10.4161/cc.8.20.9761⟩. ⟨hal-01431955⟩

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