Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Toxics Année : 2016

Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action

Caroline Vignet

Résumé

Polycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations. Reproductive traits were analyzed at individual, tissue and molecular levels. Reproductive success and cumulative eggs number were disrupted after exposure to all three fractions, albeit to various extents depending on the fraction and concentrations. Histological analyses revealed ovary maturation defects after exposure to all three fractions as well as degeneration after exposure to a pyrolytic fraction. In testis, hypoplasia was observed after exposure to petrogenic fractions. Genes expression analysis in gonads has allowed us to establish common pathways such as endocrine disruption or differentiation/maturation defects. Taken altogether, these results indicate that PAHs can indeed disrupt fish reproduction and that different fractions trigger different pathways resulting in different effects.
Fichier principal
Vignette du fichier
VignetCaroline_LarcherThibault_DavailBlandine_etal_2016.pdf (2.17 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01425791 , version 1 (20-12-2019)

Licence

Paternité

Identifiants

Citer

Caroline Vignet, Thibaut Larcher, Blandine Davail, Lucette Joassard, Karyn Le Menach, et al.. Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action. Toxics, 2016, 4 (4), pp.26. ⟨10.3390/toxics4040026⟩. ⟨hal-01425791⟩
158 Consultations
54 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More