Advances recently witnessed in pervasive and ubiquitous information processing, driven by major breakthroughs in current cyber-physical systems (CPS) are paving the way towards a more hospitable and sustainable future based on a more efficient management of our environment: homes, work places, public areas, etc. Still, many advances have to be made to tackle several scientific challenges and to address related social, legal and ethical concerns attached to such highly dynamic networked service-oriented human-aware CPS. Towards this ends, LAAS-CNRS has launched a comprehensive and innovative multidisciplinary research program entitled ADREAM: Architectures for Dynamic Resilient Embedded Autonomous Mobile systems. This paper illustrates several of these challenges and briefly presents the research activities conducted as part of the ADREAM program, with a special highlight on dependability and resilience issues.