Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Polymer Chemistry Année : 2016

Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

Résumé

Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces.

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Polymères
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Dates et versions

hal-01416279 , version 1 (14-12-2016)

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Loïc Pichavant, Hélène Carrié, Marie-Christine Durrieu, Valérie Héroguez. Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials . Polymer Chemistry, 2016, 7 (45), pp.7019-7028. ⟨10.1039/C6PY01774F⟩. ⟨hal-01416279⟩

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