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              <p>The functionalization of alkoxyamines prior to nitroxide-mediated polymerization (NMP) induces important structural variations when compared to the parent molecules. This may have important consequences on the design of functionalized materials by pre-functionalization. In this context, a wide range of amide-functionalized alkoxyamines (a functionality often obtained after conjugation from COOH- and N-succinimidyl-containing alkoxyamines) based on the nitroxide SG1 (N-tert-butyl-N-(1-diethyl phosphono-2,2-dimethylpropyl) nitroxide) have been synthesized and their dissociation rate constants (k(d)) have been determined. To rationalize their reactivity, a multi-parameter procedure was applied and enabled to discriminate disubstituted amide-functionalized alkoxyamines from monosubstituted ones. Monosubstituted alkoxyamines exhibited lower k(d) than their disubstituted counterparts (E-a increase of similar to 7-10 kJ mol(-1)) because of the occurrence of intramolecular hydrogen bonding (IHB) between the alkyl and the nitroxide fragments. NMP of styrene, n-butyl acrylate and methyl methacrylate with a small amount of acrylonitrile was then successfully performed from two representative secondary SG1-based alkoxyamines employed for conjugation: namely AMA (COOH-containing) and AMA-NHS (N-succinimidyl derivative), and compared to polymerizations initiated with AMA-Gem, an AMA-based alkoxyamine pre-functionalized with the anticancer drug Gemcitabine (Gem) and subjected to IHB. Although AMA-NHS showed the best results due to its lower Ea, the strong polarity of the Gem moiety that counter-balanced the detrimental effect of IHB over its kd still allowed for a reasonable control.</p>
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