Toward a theory of organisms: Three founding principles in search of a useful integration - Archive ouverte HAL
Article Dans Une Revue Progress in Biophysics and Molecular Biology Année : 2016

Toward a theory of organisms: Three founding principles in search of a useful integration

Résumé

Organisms, be they uni-or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms proposed in this issue, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.
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hal-01413497 , version 1 (09-12-2016)
hal-01413497 , version 2 (30-01-2017)

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Ana Soto, Giuseppe Longo, Paul-Antoine Miquel, Maël Montévil, Matteo Mossio, et al.. Toward a theory of organisms: Three founding principles in search of a useful integration. Progress in Biophysics and Molecular Biology, 2016, "From the century of the genome to the century of the organism: New theoretical approaches", a Special issue, 122 (1), pp.77-82. ⟨10.1016/j.pbiomolbio.2016.07.006⟩. ⟨hal-01413497v2⟩
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