Monte Carlo simulations guided by imaging to predict the in vitro ranking of radiosensitizing nanoparticles - Archive ouverte HAL
Article Dans Une Revue International Journal of Nanomedicine Année : 2016

Monte Carlo simulations guided by imaging to predict the in vitro ranking of radiosensitizing nanoparticles

Résumé

This article addresses the in silico–in vitro prediction issue of organometallic nanoparticles (NPs)-based radiosensitization enhancement. The goal was to carry out computational experiments to quickly identify efficient nanostructures and then to preferentially select the most promising ones for the subsequent in vivo studies. To this aim, this interdisciplinary article introduces a new theoretical Monte Carlo computational ranking method and tests it using 3 different organometallic NPs in terms of size and composition. While the ranking predicted in a classical theoretical scenario did not fit the reference results at all, in contrast, we showed for the first time how our accelerated in silico virtual screening method, based on basic in vitro experimental data (which takes into account the NPs cell biodistribution), was able to predict a relevant ranking in accordance with in vitro clonogenic efficiency. This corroborates the pertinence of such a prior ranking method that could speed up the preclinical development of NPs in radiation therapy.

Domaines

Cancer
Fichier principal
Vignette du fichier
IJN-111320-monte-carlo-simulations-guided-by-imaging-to-predict-the-in-_111816.pdf (7.93 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01407060 , version 1 (07-12-2016)

Identifiants

Citer

Paul Retif, Aurélie Reinhard, Héna Paquot, Valérie Jouan-Hureaux, Alicia Chateau, et al.. Monte Carlo simulations guided by imaging to predict the in vitro ranking of radiosensitizing nanoparticles. International Journal of Nanomedicine, 2016, 11, pp.6169-6179. ⟨10.2147/IJN.S111320⟩. ⟨hal-01407060⟩
229 Consultations
152 Téléchargements

Altmetric

Partager

More