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Article Dans Une Revue Journal of the American Chemical Society Année : 2016

Salt-Excluding Artificial Water Channels Exhibiting Enhanced Dipolar Water and Proton Translocation

Erol Licsandru
  • Fonction : Auteur
Istvan Kocsis
  • Fonction : Auteur
Samuel Murail
Yves-Marie Legrand
Arie van Der Lee
Daniel Tsai
  • Fonction : Auteur
Marc Baaden
Manish Kumar
Mihail Barboiu

Résumé

Aquaporins (AQPs) are biological water channels known for fast water transport (similar to 10(8)-10(9) molecules/s/channel) with ion exclusion. Few synthetic channels have been designed to mimic this high water permeability, and none reject ions at a significant level. Selective water translocation has previously been shown to depend on water-wires spanning the AQP pore that reverse their orientation, combined with correlated channel motions. No quantitative correlation between the dipolar orientation of the water-wires and their effects on water and proton translocation has been reported. Here, we use complementary X-ray structural data, bilayer transport experiments, and molecular dynamics (MD) simulations to gain key insights and quantify transport. We report artificial imidazole-quartet water channels with 2.6 angstrom pores, similar to AQP channels, that encapsulate oriented dipolar water-wires in a confined chiral conduit. These channels are able to transport 106 water molecules/s, which is within 2 orders of magnitude of AQPs' rates, and reject all ions except protons. The proton conductance is high (similar to 5 H+/s/channel) and approximately half that of the M2 proton channel at neutral pH. Chirality is a key feature influencing channel efficiency.

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Chimie
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Dates et versions

hal-01400466 , version 1 (13-01-2023)

Identifiants

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Erol Licsandru, Istvan Kocsis, Yue-Xiao Shen, Samuel Murail, Yves-Marie Legrand, et al.. Salt-Excluding Artificial Water Channels Exhibiting Enhanced Dipolar Water and Proton Translocation. Journal of the American Chemical Society, 2016, 138 (16), pp.5403 - 5409. ⟨10.1021/jacs.6b01811⟩. ⟨hal-01400466⟩
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