Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Catalysis Année : 2015

Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple

Résumé

A convenient one-pot system has been developed, allowing the synthesis of highly substituted dihydropyridines via a C-H activation/6 pi-electrocyclization pathway. The reaction proceeds with high regioselectivity, and we disclose the first example of isolated dihydropyridines lacking substitution in the 2 position. Moreover, the use of a simple well-defined low-valent cobalt complex without the need for reducing agents or additives in combination with computational studies provides a clearer insight into the C-H activation pathway than was previously reported.
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hal-01397966 , version 1 (16-11-2016)

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Brendan J. Fallon, Jean-Baptiste Garsi, Etienne Derat, Muriel Amatore, Corinne Aubert, et al.. Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple. ACS Catalysis, 2015, 5 (12), pp.7493-7497. ⟨10.1021/acscatal.5b02138⟩. ⟨hal-01397966⟩
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