Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue American Journal of Obstetrics and Gynecology Année : 2015

Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?

Charles Garabedian
Rony Sfeir
  • Fonction : Auteur
Carole Langlois
Arnaud Bonnard
  • Fonction : Auteur
Naziha Khen-Dunlop
  • Fonction : Auteur
Thomas Gelas
  • Fonction : Auteur
Laurent Michaud
  • Fonction : Auteur
Frédéric Auber
  • Fonction : Auteur
Frédéric Gottrand
  • Fonction : Auteur
Véronique Houfflin-Debarge
  • Fonction : Auteur

Résumé

OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA.

STUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year.

RESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3%; 82.2% of EA type I were diagnosed prenatally compared with 17.9% of EA type III (P < .001). Transfer after birth was lower in case of prenatal diagnosis (25.6% vs 82.5%; P < .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P < .001). The composite variables were higher in prenatal diagnosis subset (44% vs 27.6%; P = .003) and in EA type I than in type III (58.1% vs 28.3%; P < .001).

CONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.

Fichier non déposé

Dates et versions

hal-01392303 , version 1 (04-11-2016)

Identifiants

Citer

Charles Garabedian, Rony Sfeir, Carole Langlois, Arnaud Bonnard, Naziha Khen-Dunlop, et al.. Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?. American Journal of Obstetrics and Gynecology, 2015, 212 (3), pp.340.e1-340.e7. ⟨10.1016/j.ajog.2014.09.030⟩. ⟨hal-01392303⟩

Collections

UNIV-ANGERS HIFIH
44 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More