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Article Dans Une Revue Blood Cancer Journal Année : 2015

Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance

Aline Tanguy-Schmidt
Norbert Ifrah
  • Fonction : Auteur
  • PersonId : 992780
Gilles Renier
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  • PersonId : 920215
Alain Chevailler
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  • PersonId : 991985

Résumé

Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients. All patients had spinal radiographs and bone mineral density measurement in addition to gammopathy assessment. At least one prevalent non-traumatic vertebral fracture was discovered in 18.4% patients and equally distributed between men and women. Fractured patients were older, had a lower bone density and had also more frequently a lambda light chain isotype. Compared with patients with κ light chain, the odds ratio of being fractured for patients with λ light chain was 4.32 (95% confidence interval 1.80-11.16; P=0.002). These results suggest a high prevalence of non-traumatic vertebral fractures in MGUS associated with lambda light chain isotype and not only explained by low bone density.

Dates et versions

hal-01392246 , version 1 (04-11-2016)

Identifiants

Citer

J Piot, Mathieu Royer, Aline Tanguy-Schmidt, Emmanuel Hoppé, Martine Gardembas, et al.. Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance. Blood Cancer Journal, 2015, 5, pp.e345. ⟨10.1038/bcj.2015.71⟩. ⟨hal-01392246⟩
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