<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01390585</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T05:19:37+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Emerging role of G protein-coupled receptors in microvascular myogenic tone</title>
            <author role="aut">
              <persName>
                <forename type="first">Gilles</forename>
                <surname>Kauffenstein</surname>
              </persName>
              <email type="md5">58059e934d5509e3ba2a7fde2ac76b1f</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1198587</idno>
              <idno type="halauthorid" notation="string">1071397-1198587</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4994-8305</idno>
              <affiliation ref="#struct-179941"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ismail</forename>
                <surname>Laher</surname>
              </persName>
              <idno type="halauthorid">1075610-0</idno>
              <affiliation ref="#struct-366034"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">K.</forename>
                <surname>Matrougui</surname>
              </persName>
              <idno type="halauthorid">1075611-0</idno>
              <affiliation ref="#struct-424938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Guérineau</surname>
              </persName>
              <email type="md5">2810769bc1142841a3ed71db29dd459f</email>
              <email type="domain">igf.cnrs.fr</email>
              <idno type="idhal" notation="string">nathalie-c-guerineau</idno>
              <idno type="idhal" notation="numeric">172564</idno>
              <idno type="halauthorid" notation="string">1075612-172564</idno>
              <idno type="IDREF">https://www.idref.fr/06998798X</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2517-4210</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=mE_gRUAAAAAJ</idno>
              <affiliation ref="#struct-179941"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Daniel</forename>
                <surname>Henrion</surname>
              </persName>
              <email type="md5">966230d6fe3fb36fe716e617bab0925b</email>
              <email type="domain">univ-angers.fr</email>
              <idno type="idhal" notation="string">daniel-henrion</idno>
              <idno type="idhal" notation="numeric">178861</idno>
              <idno type="halauthorid" notation="string">1868-178861</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1094-0285</idno>
              <idno type="IDREF">https://www.idref.fr/092696252</idno>
              <affiliation ref="#struct-179941"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Okina</forename>
                <surname>Univ Angers</surname>
              </persName>
              <email type="md5">b5db9c104e451c4c3e7e86bba508166f</email>
              <email type="domain">contact.univ-angers.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2016-11-02 11:10:41</date>
              <date type="whenModified">2026-04-14 15:24:06</date>
              <date type="whenReleased">2016-11-02 11:10:41</date>
              <date type="whenProduced">2012</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888209"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="300611">
                <persName>
                  <forename>Okina</forename>
                  <surname>Univ Angers</surname>
                </persName>
                <email type="md5">b5db9c104e451c4c3e7e86bba508166f</email>
                <email type="domain">contact.univ-angers.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01390585</idno>
            <idno type="halUri">https://hal.science/hal-01390585</idno>
            <idno type="halBibtex">kauffenstein:hal-01390585</idno>
            <idno type="halRefHtml">&lt;i&gt;Cardiovascular Research&lt;/i&gt;, 2012, 95 (2), pp.223 - 32. &lt;a target="_blank" href="https://dx.doi.org/10.1093/cvr/cvs152"&gt;&amp;#x27E8;10.1093/cvr/cvs152&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cardiovascular Research, 2012, 95 (2), pp.223 - 32. &amp;#x27E8;10.1093/cvr/cvs152&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Emerging role of G protein-coupled receptors in microvascular myogenic tone</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Gilles</forename>
                    <surname>Kauffenstein</surname>
                  </persName>
                  <email type="md5">58059e934d5509e3ba2a7fde2ac76b1f</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1198587</idno>
                  <idno type="halauthorid" notation="string">1071397-1198587</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4994-8305</idno>
                  <affiliation ref="#struct-179941"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ismail</forename>
                    <surname>Laher</surname>
                  </persName>
                  <idno type="halauthorid">1075610-0</idno>
                  <affiliation ref="#struct-366034"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">K.</forename>
                    <surname>Matrougui</surname>
                  </persName>
                  <idno type="halauthorid">1075611-0</idno>
                  <affiliation ref="#struct-424938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Guérineau</surname>
                  </persName>
                  <email type="md5">2810769bc1142841a3ed71db29dd459f</email>
                  <email type="domain">igf.cnrs.fr</email>
                  <idno type="idhal" notation="string">nathalie-c-guerineau</idno>
                  <idno type="idhal" notation="numeric">172564</idno>
                  <idno type="halauthorid" notation="string">1075612-172564</idno>
                  <idno type="IDREF">https://www.idref.fr/06998798X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2517-4210</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=mE_gRUAAAAAJ</idno>
                  <affiliation ref="#struct-179941"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Daniel</forename>
                    <surname>Henrion</surname>
                  </persName>
                  <email type="md5">966230d6fe3fb36fe716e617bab0925b</email>
                  <email type="domain">univ-angers.fr</email>
                  <idno type="idhal" notation="string">daniel-henrion</idno>
                  <idno type="idhal" notation="numeric">178861</idno>
                  <idno type="halauthorid" notation="string">1868-178861</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1094-0285</idno>
                  <idno type="IDREF">https://www.idref.fr/092696252</idno>
                  <affiliation ref="#struct-179941"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11528</idno>
                <idno type="issn">0008-6363</idno>
                <title level="j">Cardiovascular Research</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">95</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">223 - 32</biblScope>
                  <date type="datePub">2012</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/cvr/cvs152</idno>
              <idno type="okina">ua8234</idno>
              <idno type="pubmed">22637750</idno>
              <idno type="pubmedcentral">PMC3888209</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Calcium</term>
                <term xml:lang="en">Microvessels</term>
                <term xml:lang="en">Signal Transduction</term>
                <term xml:lang="en">Mechanotransduction</term>
                <term xml:lang="en">Animals</term>
                <term xml:lang="en">Humans</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART.ARTREV">Journal articles - Review article</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Blood flow autoregulation results from the ability of resistance arteries to reduce or increase their diameters in response to changes in intravascular pressure. The mechanism by which arteries maintain a constant blood flow to organs over a range of pressures relies on this myogenic response, which defines the intrinsic property of the smooth muscle to contract in response to stretch. The resistance to flow created by myogenic tone (MT) prevents tissue damage and allows the maintenance of a constant perfusion, despite fluctuations in arterial pressure. Interventions targeting MT may provide a more rational therapeutic approach in vascular disorders, such as hypertension, vasospasm, chronic heart failure, or diabetes. Despite its early description by Bayliss in 1902, the cellular and molecular mechanisms underlying MT remain poorly understood. We now appreciate that MT requires a complex mechanotransduction converting a physical stimulus (pressure) into a biological response (change in vessel diameter). Although smooth muscle cell depolarization and a rise in intracellular calcium concentration are recognized as cornerstones of the myogenic response, the role of wall strain-induced formation of vasoactive mediators is less well established. The vascular system expresses a large variety of Class 1 G protein-coupled receptors (GPCR) activated by an eclectic range of chemical entities, including peptides, lipids, nucleotides, and amines. These messengers can function in blood vessels as vasoconstrictors. This review focuses on locally generated GPCR agonists and their proposed contributions to MT. Their interplay with pivotal G(q-11) and G(12-13) protein signalling is also discussed.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-179941" status="OLD">
          <orgName>Biologie Neurovasculaire et Mitochondriale Intégrée</orgName>
          <orgName type="acronym">BNMI</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation name="UMR6214" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-366034" status="VALID">
          <idno type="IdRef">028326792</idno>
          <idno type="ISNI">0000000122889830</idno>
          <idno type="ROR">https://ror.org/03rmrcq20</idno>
          <idno type="Wikidata">Q391028</idno>
          <orgName>University of British Columbia [Canada]</orgName>
          <orgName type="acronym">UBC</orgName>
          <date type="start">1908-01-01</date>
          <desc>
            <address>
              <addrLine>Vancouver Campus, 2329 West Mall, Vancouver, BC, V6T 1Z4 / Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">https://www.ubc.ca</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-424938" status="VALID">
          <idno type="ROR">https://ror.org/04vmvtb21</idno>
          <orgName>Tulane University</orgName>
          <desc>
            <address>
              <addrLine>6823 St Charles Ave, New Orleans, LA 70118</addrLine>
              <country key="US"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>