In the search for more and better ways of nurturing enterprising people and especially for developing entrepreneurs, the role of education and training is seen as absolutely essential. After reviewing major key research issues about entrepreneurship education and training implementation, we present a specific initiative built on the introduction of a new venture creation programme in higher education. Such an experimental programme allows the implementation of a cross-disciplinary area of training, which drives students to adopt an integrative and holistic approach for business venture creation and development.