Polyisobutylcyanoacrylate nanoparticles as drug carriers: influence of sulfur dioxide on the physico-chemical characteristics of ciprofloxacin- and doxorubicin-loaded nanoparticles - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Pharmaceutics Année : 1998

Polyisobutylcyanoacrylate nanoparticles as drug carriers: influence of sulfur dioxide on the physico-chemical characteristics of ciprofloxacin- and doxorubicin-loaded nanoparticles

Résumé

The amount of sulfur dioxide present in isobutylcyanoacrylate monomer was examined for the entrapment of ciprofloxacin and doxorubicin into poly(isobutylcyanoacrylate) nanoparticles obtained by emulsion polymerization. In fact, SO 2 , commonly used as a polymerization inhibitor, was shown to be a crucial factor modulating the polymerization process. In this report, its optimal concentration to have reproducible preparations regarding size and highest association extent was about 0.5% for both drugs.

Dates et versions

hal-01383588 , version 1 (18-10-2016)

Identifiants

Citer

Marie-Estelle Page-Clisson, Stéphane Gibaud, Huguette Pinto-Alphandary, Colette Weingarten, Patrick Couvreur. Polyisobutylcyanoacrylate nanoparticles as drug carriers: influence of sulfur dioxide on the physico-chemical characteristics of ciprofloxacin- and doxorubicin-loaded nanoparticles. International Journal of Pharmaceutics, 1998, 166, pp.117-120. ⟨10.1016/S0378-5173(98)00028-3⟩. ⟨hal-01383588⟩
53 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More