Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Developmental Biology Année : 2009

Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography

Résumé

Recurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In ~50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of mammalian reproduction. Indeed, fertility can be considered as a quantitative feature resulting from the interaction of genetic, epigenetic and environmental factors. Herein, we identified Quantitative Trait Loci (QTL) associated with diverse embryonic lethality phenotypes and the subsequent embryonic resorption in 39 inter-specific recombinant congenic mice strains, using in vivo ultrasound bio-microscopy. The short chromosomal intervals related to the phenotypes will facilitate the study of a restricted number of candidate genes which are potentially dysregulated in patients affected by RSA.
Fichier principal
Vignette du fichier
ft623.pdf (2.23 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01370041 , version 1 (21-09-2016)

Identifiants

Citer

Paul Laissue, Gaétan Burgio, David L 'Hôte, Gilles Renault, Carmen Marchiol-Fournigault, et al.. Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography. International Journal of Developmental Biology, 2009, 53 (4), pp.623-629. ⟨10.1387/ijdb.082613pl⟩. ⟨hal-01370041⟩
157 Consultations
154 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More