ILLUMINATION PROFILE CHARACTERIZATION OF A LIGHT DEVICE FOR THE DOSIMETRY OF INTRA-PLEURAL PHOTODYNAMIC THERAPY FOR MESOTHELIOMA - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Photodiagnosis and Photodynamic Therapy Année : 2016

ILLUMINATION PROFILE CHARACTERIZATION OF A LIGHT DEVICE FOR THE DOSIMETRY OF INTRA-PLEURAL PHOTODYNAMIC THERAPY FOR MESOTHELIOMA

Résumé

BACKGROUND: Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could be the first step towards optimizing dosimetry. Here we propose a characterization method of the illumination profile of a specific light device. METHODS: The light wand, made of a cylindrical diffuser located inside an endotracheal tube, was fixed in a tank filled with dilute 0.01% intralipid. Light dosimetry was performed around the tip of the wand using two complementary methods: direct measurements of light power with an isotropic probe and measurements of light distribution characterization. RESULTS: Dosimetry with the isotropic probe showed an ellipse-shaped illumination. An optimized effective attenuation coefficient was deduced. Combined with the spatial representation, a theoretical illumination profile was established with iso-surfaces of fluence rate, defining a gradient light dose according to the distance from the diffuser. CONCLUSION: A theoretical illumination profile of a light device was established and could be part of an intra-operative dosimetry system to improve light delivery during intrapleural PDT. Copyright © 2016. Published by Elsevier B.V.

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Cancer
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hal-01366617 , version 1 (15-09-2016)

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  • HAL Id : hal-01366617 , version 1

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Camille Munck, Serge Mordon, Nacim Betrouni. ILLUMINATION PROFILE CHARACTERIZATION OF A LIGHT DEVICE FOR THE DOSIMETRY OF INTRA-PLEURAL PHOTODYNAMIC THERAPY FOR MESOTHELIOMA. Photodiagnosis and Photodynamic Therapy, 2016. ⟨hal-01366617⟩
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