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Article Dans Une Revue Nature Neuroscience Année : 2015

Calcium dynamics in astrocyte processes during neurovascular coupling

Résumé

Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca2+) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca2+ signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca2+ sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca2+ increases in astrocyte processes but not in somata. These Ca2+ increases systematically precede the onset of functional hyperemia by 1-2 s, reestablishing astrocytes as potential regulators of neurovascular coupling.

Dates et versions

hal-01362700 , version 1 (09-09-2016)

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Citer

Yo Otsu, Kiri Couchman, Declan G. Lyons, Mayeul Collot, Amit Agarwal, et al.. Calcium dynamics in astrocyte processes during neurovascular coupling. Nature Neuroscience, 2015, 18 (2), pp.210-218. ⟨10.1038/nn.3906⟩. ⟨hal-01362700⟩
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