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Article Dans Une Revue Neural plasticity Année : 2016

Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study

Résumé

Glutamatergic gliotransmission, that is the release of glutamate from perisynaptic astro-cyte processes in an activity-dependent manner, has emerged as a potentially crucial signal-ing pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmit-ter patwhays: (i) modulations of synaptic release and (ii) postynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. Our model predicts that both pathways could profoundly affect both short-and long-term plasticity. In particular, activity-dependent glutamate release from astrocytes, could dramatically change spike-timing–dependent plasticity, turning potentiation into depression (and vice versa) for the same protocol.
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Dates et versions

hal-01353306 , version 1 (11-08-2016)

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Maurizio de Pittà, Nicolas Brunel. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural plasticity, 2016, ⟨10.1155/2016/7607924⟩. ⟨hal-01353306⟩
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