This chapter evaluates the risk of traffic injuries as the ratio between amount of casualties and mobility in the Rhône County, using medical crash data and travel surveys. Rates are estimated for car occupants, pedestrians, cyclists and powered two-wheeler (PTW) riders, separately for three injury categories. The exposure measures are number of trips, distance traveled or time spent traveling with a given means of transport. These are obtained from a regional travel survey (RTS). A road trauma registry has been in operation since 1996 and has been certified by the relevant French authority. Crash data is sourced from a road trauma registry, including outpatients and inpatients, in the Rhône county. Ratios between injury rates for each user type and for car occupants showed differences according to which exposure measure is used. The amount of excess risk for PTW riders is quantified and is very high.