The purpose of this paper is to describe Math High School (MHS), an experimental teaching project promoted by the research group of Mathematics Education at the University of Salerno. MHS has been devised to surpass the dichotomy between scientific and humanistic cultures, responding to the daily, social, politic, national and world challenges. In this process, Mathematics is the common denominator between the two cultures. In this paper we describe the theoretical context of MHS, the education innovations of the adopted methodologies and the first year experimentation activities.