Tandem ion mobility spectrometry coupled to laser excitation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Review of Scientific Instruments Année : 2015

Tandem ion mobility spectrometry coupled to laser excitation

Résumé

This manuscript describes a new experimental setup that allows to perform tandem ion mobility spectrometry (IMS) measurements and which is coupled to a high resolution time-of-flight mass spectrometer. It consists of two 79 cm long drift tubes connected by a dual ion funnel assembly. The setup was built to permit laser irradiation of the ions in the transfer region between the two drift tubes. This geometry allows selecting ions according to their ion mobility in the first drift tube, to irradiate selected ions, and examine the ion mobility of the product ions in the second drift tube. Activation by collision is possible in the same region (between the two tubes) and between the second tube and the time-of-flight. IMS-IMS experiments on Ubiquitin are reported. We selected a given isomer of charge state +7 and explored its structural rearrangement following collisional activation between the two drift tubes. An example of IMS-laser-IMS experiment is reported on eosin Y, where laser irradiation was used to produce radical ions by electron photodetachment starting from doubly deprotonated species. This allowed measuring the collision cross section of the radical photo-product, which cannot be directly produced with an electrospray source.
Fichier principal
Vignette du fichier
IMS Laser IMS.pdf (784.56 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01344740 , version 1 (20-07-2016)

Identifiants

Citer

Anne-Laure Simon, Fabien Chirot, Chang Min Choi, Christian Clavier, Marc Barbaire, et al.. Tandem ion mobility spectrometry coupled to laser excitation. Review of Scientific Instruments, 2015, 86 (9), pp.Article Number: 094101. ⟨10.1063/1.4930604⟩. ⟨hal-01344740⟩
71 Consultations
319 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More