Article Dans Une Revue Veterinary Research Année : 2015

Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle

Zhidong Zhang
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Claudia Doel
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John B. Bashiruddin
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Résumé

AbstractThe factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1–4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was detected and peaked at 1 or 2 days post infection and rapidly declined thereafter. In contract, serum IL-10 levels in non-carrier cattle (n = 21) were very low or undetectable during the same period.

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hal-01341441 , version 1 (04-07-2016)

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Zhidong Zhang, Claudia Doel, John B. Bashiruddin. Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle. Veterinary Research, 2015, 46 (1), pp.132. ⟨10.1186/s13567-015-0276-y⟩. ⟨hal-01341441⟩

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